Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression

Lily Watson; Athimalaipet V ramanan; Elizabeth Oliver; Francisca Segers; Gareth W. Jones; Christine Chew; Anu Goenka

doi:10.1002/eji.202451609

Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression

Lily Watson, Athimalaipet V ramanan, Elizabeth Oliver, Francisca Segers, Gareth W. Jones, Christine Chew^*, Anu Goenka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

Original language	English
Article number	e202451609
Number of pages	5
Journal	European Journal of Immunology
Volume	55
Issue number	4
DOIs	https://doi.org/10.1002/eji.202451609
Publication status	Published - 21 Apr 2025

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@article{8d18cecd7bc24f0990f30ba102b7c1ae,

title = "Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression",

abstract = "In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.",

author = "Lily Watson and {V ramanan}, Athimalaipet and Elizabeth Oliver and Francisca Segers and Jones, {Gareth W.} and Christine Chew and Anu Goenka",

year = "2025",

month = apr,

day = "21",

doi = "10.1002/eji.202451609",

language = "English",

volume = "55",

journal = "European Journal of Immunology",

issn = "0014-2980",

publisher = "Wiley-Blackwell",

number = "4",

}

Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression. / Watson, Lily; V ramanan, Athimalaipet; Oliver, Elizabeth et al.
In: European Journal of Immunology, Vol. 55, No. 4, e202451609, 21.04.2025.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression

AU - Watson, Lily

AU - V ramanan, Athimalaipet

AU - Oliver, Elizabeth

AU - Segers, Francisca

AU - Jones, Gareth W.

AU - Chew, Christine

AU - Goenka, Anu

PY - 2025/4/21

Y1 - 2025/4/21

N2 - In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

AB - In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

U2 - 10.1002/eji.202451609

DO - 10.1002/eji.202451609

M3 - Article (Academic Journal)

C2 - 40257409

SN - 0014-2980

VL - 55

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 4

M1 - e202451609

ER -

Pamidronate‐Induced Clinical Remission in Chronic Non‐bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T‐Cell Receptor Expression

Abstract

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