PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

PANC Study Collaborative; Angeliki Kosti; Aditya Borakati; Aarti Varma; Aayush Gupta; Abdalla Mustafa; Abdul Hakeem; Abdul Quddus; Abdullah Bin Sahl; Abhijeet Beniwal; Abidemi Adesuyi; Ada Maria Krzak; Adam Brooks; Adam Frampton; Adam Gadhvi; Adam Talbot; Ahmed Elnogoomi; Ahmed Mahgoub; Ahmed Naqvi; Ahmed Pervez; Ahmed Salman Bodla; Ahmed Taha; Ahmed Tawfik; Aishwarya Prabhu; Aiysha Puri; Ajay Belgaumkar; Ajay Gupta; Alan McCrorie; Alasdair Findlay; Albert Healey; Alexandra De Prendergast; Alexia Farrugia; Alexios Dosis; Alfie Adiamah; Ali Sallam; Alicia Wong; Alison Bradley; Allie Martin; Alma Collins; Altaf Awan; Amanda Bond; Amanda Koh; Amar Kourdouli; Ameet G Patel; Amenah Dhannoon; Amjad Khalil; Amlan Banerjee; Amnah Khan; Amr Elserafy; Amro Alamassi; Amy Owen; Marianne L Hollyman; et al

doi:10.1093/bjsopen/zrad008

PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

PANC Study Collaborative, Angeliki Kosti, Aditya Borakati, Aarti Varma, Aayush Gupta, Abdalla Mustafa, Abdul Hakeem, Abdul Quddus, Abdullah Bin Sahl, Abhijeet Beniwal, Abidemi Adesuyi, Ada Maria Krzak, Adam Brooks, Adam Frampton, Adam Gadhvi, Adam Talbot, Ahmed Elnogoomi, Ahmed Mahgoub, Ahmed Naqvi, Ahmed PervezAhmed Salman Bodla, Ahmed Taha, Ahmed Tawfik, Aishwarya Prabhu, Aiysha Puri, Ajay Belgaumkar, Ajay Gupta, Alan McCrorie, Alasdair Findlay, Albert Healey, Alexandra De Prendergast, Alexia Farrugia, Alexios Dosis, Alfie Adiamah, Ali Sallam, Alicia Wong, Alison Bradley, Allie Martin, Alma Collins, Altaf Awan, Amanda Bond, Amanda Koh, Amar Kourdouli, Ameet G Patel, Amenah Dhannoon, Amjad Khalil, Amlan Banerjee, Amnah Khan, Amr Elserafy, Amro Alamassi, Amy Owen, Marianne L Hollyman^*, et al

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Abstract

Background

Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.

Methods

All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.

Results

A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.

Conclusion

Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.

Original language	English
Article number	zrad008
Journal	BJS Open
Early online date	10 May 2023
DOIs	https://doi.org/10.1093/bjsopen/zrad008
Publication status	Published - 1 Jun 2023

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Collaborative, PANC. S., Kosti, A., Borakati, A., Varma, A., Gupta, A., Mustafa, A., Hakeem, A., Quddus, A., Sahl, A. B., Beniwal, A., Adesuyi, A., Krzak, A. M., Brooks, A., Frampton, A., Gadhvi, A., Talbot, A., Elnogoomi, A., Mahgoub, A., Naqvi, A., ... al, E. (2023). PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK. BJS Open, Article zrad008. https://doi.org/10.1093/bjsopen/zrad008

@article{307d04d71b2e4e65add175d0e5a54ed0,

title = "PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK",

abstract = "BackgroundAcute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.MethodsAll patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.ResultsA total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.ConclusionMost patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.",

author = "Collaborative, \{PANC Study\} and Angeliki Kosti and Aditya Borakati and Aarti Varma and Aayush Gupta and Abdalla Mustafa and Abdul Hakeem and Abdul Quddus and Sahl, \{Abdullah Bin\} and Abhijeet Beniwal and Abidemi Adesuyi and Krzak, \{Ada Maria\} and Adam Brooks and Adam Frampton and Adam Gadhvi and Adam Talbot and Ahmed Elnogoomi and Ahmed Mahgoub and Ahmed Naqvi and Ahmed Pervez and Bodla, \{Ahmed Salman\} and Ahmed Taha and Ahmed Tawfik and Aishwarya Prabhu and Aiysha Puri and Ajay Belgaumkar and Ajay Gupta and Alan McCrorie and Alasdair Findlay and Albert Healey and Prendergast, \{Alexandra De\} and Alexia Farrugia and Alexios Dosis and Alfie Adiamah and Ali Sallam and Alicia Wong and Alison Bradley and Allie Martin and Alma Collins and Altaf Awan and Amanda Bond and Amanda Koh and Amar Kourdouli and Patel, \{Ameet G\} and Amenah Dhannoon and Amjad Khalil and Amlan Banerjee and Amnah Khan and Amr Elserafy and Amro Alamassi and Amy Owen and Hollyman, \{Marianne L\} and et al",

year = "2023",

month = jun,

day = "1",

doi = "10.1093/bjsopen/zrad008",

language = "English",

journal = "BJS Open",

issn = "2474-9842",

publisher = "Oxford University Press",

}

Collaborative, PANCS, Kosti, A, Borakati, A, Varma, A, Gupta, A, Mustafa, A, Hakeem, A, Quddus, A, Sahl, AB, Beniwal, A, Adesuyi, A, Krzak, AM, Brooks, A, Frampton, A, Gadhvi, A, Talbot, A, Elnogoomi, A, Mahgoub, A, Naqvi, A, Pervez, A, Bodla, AS, Taha, A, Tawfik, A, Prabhu, A, Puri, A, Belgaumkar, A, Gupta, A, McCrorie, A, Findlay, A, Healey, A, Prendergast, AD, Farrugia, A, Dosis, A, Adiamah, A, Sallam, A, Wong, A, Bradley, A, Martin, A, Collins, A, Awan, A, Bond, A, Koh, A, Kourdouli, A, Patel, AG, Dhannoon, A, Khalil, A, Banerjee, A, Khan, A, Elserafy, A, Alamassi, A, Owen, A, Hollyman, ML & al, E 2023, 'PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK', BJS Open. https://doi.org/10.1093/bjsopen/zrad008

TY - JOUR

T1 - PANC Study (Pancreatitis: A National Cohort Study)

T2 - national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

AU - Collaborative, PANC Study

AU - Kosti, Angeliki

AU - Borakati, Aditya

AU - Varma, Aarti

AU - Gupta, Aayush

AU - Mustafa, Abdalla

AU - Hakeem, Abdul

AU - Quddus, Abdul

AU - Sahl, Abdullah Bin

AU - Beniwal, Abhijeet

AU - Adesuyi, Abidemi

AU - Krzak, Ada Maria

AU - Brooks, Adam

AU - Frampton, Adam

AU - Gadhvi, Adam

AU - Talbot, Adam

AU - Elnogoomi, Ahmed

AU - Mahgoub, Ahmed

AU - Naqvi, Ahmed

AU - Pervez, Ahmed

AU - Bodla, Ahmed Salman

AU - Taha, Ahmed

AU - Tawfik, Ahmed

AU - Prabhu, Aishwarya

AU - Puri, Aiysha

AU - Belgaumkar, Ajay

AU - Gupta, Ajay

AU - McCrorie, Alan

AU - Findlay, Alasdair

AU - Healey, Albert

AU - Prendergast, Alexandra De

AU - Farrugia, Alexia

AU - Dosis, Alexios

AU - Adiamah, Alfie

AU - Sallam, Ali

AU - Wong, Alicia

AU - Bradley, Alison

AU - Martin, Allie

AU - Collins, Alma

AU - Awan, Altaf

AU - Bond, Amanda

AU - Koh, Amanda

AU - Kourdouli, Amar

AU - Patel, Ameet G

AU - Dhannoon, Amenah

AU - Khalil, Amjad

AU - Banerjee, Amlan

AU - Khan, Amnah

AU - Elserafy, Amr

AU - Alamassi, Amro

AU - Owen, Amy

AU - Hollyman, Marianne L

AU - al, et

PY - 2023/6/1

Y1 - 2023/6/1

N2 - BackgroundAcute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.MethodsAll patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.ResultsA total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.ConclusionMost patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.

AB - BackgroundAcute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.MethodsAll patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.ResultsA total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.ConclusionMost patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.

U2 - 10.1093/bjsopen/zrad008

DO - 10.1093/bjsopen/zrad008

M3 - Article (Academic Journal)

C2 - 37161673

SN - 2474-9842

JO - BJS Open

JF - BJS Open

M1 - zrad008

ER -

PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

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