Panniculitis in a 3-year-old child with Fanconi anemia-associated bone marrow hypoplasia heralds transformation to acute myeloid leukemia

Lucy Webber*, Michelle Cummins, Rebecca Mann, Lindsay Shaw, Rosanna Ghinai, Caroline Mahon

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)

Abstract

Fanconi anemia is a rare, autosomal recessive genomic instability disorder characterized by congenital limb anomalies, panmyelopathy and a high risk of malignancy, principally acute myeloid leukemia. Hematologic malignancy presenting with acute febrile neutrophilic dermatosis (Sweet syndrome), both deep and superficial forms, is well described in Fanconi anemia patients but is a rare phenomenon in otherwise healthy children. We present a case of panniculitis (presumptive subcutaneous Sweet syndrome) heralding transformation to acute myeloid leukemia in a 3-year-old boy with a severe Fanconi anemia phenotype.

Original languageEnglish
Pages (from-to)725-727
Number of pages3
JournalPediatric Dermatology
Volume36
Issue number5
DOIs
Publication statusPublished - 1 Sep 2019

Keywords

  • acute myeloid leukemia
  • Fanconi anemia
  • neutrophilic disorders
  • panniculitis
  • subcutaneous Sweet syndrome

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