Abstract
The role of the tyrosine kinase pp60src in PAR-1-dependent Ca2+ entry was investigated in human platelets. pp60src plays a role in thapsigargin (TG)-evoked store-operated Ca2+ entry (SOCE), which is thought to be a major component of thrombin-evoked Ca2+ entry.
Original language | English |
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Pages (from-to) | 2695-703 |
Number of pages | 9 |
Journal | Journal of Thrombosis and Haemostasis |
Volume | 4 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2006 |
Keywords
- Egtazic Acid
- Calcium
- Humans
- Cytochalasin D
- Cytoskeleton
- Indoles
- Blood Platelets
- Peptide Fragments
- Pyrimidines
- Phosphorylation
- Protein Kinase C
- Time Factors
- Calcium Signaling
- Receptor, PAR-1
- Carbazoles
- Plasma Membrane Calcium-Transporting ATPases
- Enzyme Activation
- Enzyme Inhibitors
- Proto-Oncogene Proteins pp60(c-src)
- Thapsigargin
- Phospholipid Ethers
- Actins
- Chelating Agents
- Type C Phospholipases
- Sarcoplasmic Reticulum Calcium-Transporting ATPases