PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets

M T Harper; S O Sage

doi:10.1111/j.1538-7836.2006.02207.x

PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets

M T Harper
, S O Sage

Research output: Contribution to journal › Article (Academic Journal) › peer-review

22 Citations (Scopus)

Abstract

The role of the tyrosine kinase pp60src in PAR-1-dependent Ca2+ entry was investigated in human platelets. pp60src plays a role in thapsigargin (TG)-evoked store-operated Ca2+ entry (SOCE), which is thought to be a major component of thrombin-evoked Ca2+ entry.

Original language	English
Pages (from-to)	2695-703
Number of pages	9
Journal	Journal of Thrombosis and Haemostasis
Volume	4
Issue number	12
DOIs	https://doi.org/10.1111/j.1538-7836.2006.02207.x
Publication status	Published - Dec 2006

Keywords

Egtazic Acid
Calcium
Humans
Cytochalasin D
Cytoskeleton
Indoles
Blood Platelets
Peptide Fragments
Pyrimidines
Phosphorylation
Protein Kinase C
Time Factors
Calcium Signaling
Receptor, PAR-1
Carbazoles
Plasma Membrane Calcium-Transporting ATPases
Enzyme Activation
Enzyme Inhibitors
Proto-Oncogene Proteins pp60(c-src)
Thapsigargin
Phospholipid Ethers
Actins
Chelating Agents
Type C Phospholipases
Sarcoplasmic Reticulum Calcium-Transporting ATPases

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@article{8e4cb3c5ab094e5d930fc8a794b2c734,

title = "PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets",

abstract = "The role of the tyrosine kinase pp60src in PAR-1-dependent Ca2+ entry was investigated in human platelets. pp60src plays a role in thapsigargin (TG)-evoked store-operated Ca2+ entry (SOCE), which is thought to be a major component of thrombin-evoked Ca2+ entry.",

keywords = "Egtazic Acid, Calcium, Humans, Cytochalasin D, Cytoskeleton, Indoles, Blood Platelets, Peptide Fragments, Pyrimidines, Phosphorylation, Protein Kinase C, Time Factors, Calcium Signaling, Receptor, PAR-1, Carbazoles, Plasma Membrane Calcium-Transporting ATPases, Enzyme Activation, Enzyme Inhibitors, Proto-Oncogene Proteins pp60(c-src), Thapsigargin, Phospholipid Ethers, Actins, Chelating Agents, Type C Phospholipases, Sarcoplasmic Reticulum Calcium-Transporting ATPases",

author = "Harper, \{M T\} and Sage, \{S O\}",

year = "2006",

month = dec,

doi = "10.1111/j.1538-7836.2006.02207.x",

language = "English",

volume = "4",

pages = "2695--703",

journal = "Journal of Thrombosis and Haemostasis",

issn = "1538-7933",

publisher = "Elsevier B.V.",

number = "12",

}

PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets. / Harper, M T; Sage, S O.
In: Journal of Thrombosis and Haemostasis, Vol. 4, No. 12, 12.2006, p. 2695-703.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]

T2 - evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets

AU - Harper, M T

AU - Sage, S O

PY - 2006/12

Y1 - 2006/12

N2 - The role of the tyrosine kinase pp60src in PAR-1-dependent Ca2+ entry was investigated in human platelets. pp60src plays a role in thapsigargin (TG)-evoked store-operated Ca2+ entry (SOCE), which is thought to be a major component of thrombin-evoked Ca2+ entry.

AB - The role of the tyrosine kinase pp60src in PAR-1-dependent Ca2+ entry was investigated in human platelets. pp60src plays a role in thapsigargin (TG)-evoked store-operated Ca2+ entry (SOCE), which is thought to be a major component of thrombin-evoked Ca2+ entry.

KW - Egtazic Acid

KW - Calcium

KW - Humans

KW - Cytochalasin D

KW - Cytoskeleton

KW - Indoles

KW - Blood Platelets

KW - Peptide Fragments

KW - Pyrimidines

KW - Phosphorylation

KW - Protein Kinase C

KW - Time Factors

KW - Calcium Signaling

KW - Receptor, PAR-1

KW - Carbazoles

KW - Plasma Membrane Calcium-Transporting ATPases

KW - Enzyme Activation

KW - Enzyme Inhibitors

KW - Proto-Oncogene Proteins pp60(c-src)

KW - Thapsigargin

KW - Phospholipid Ethers

KW - Actins

KW - Chelating Agents

KW - Type C Phospholipases

KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases

U2 - 10.1111/j.1538-7836.2006.02207.x

DO - 10.1111/j.1538-7836.2006.02207.x

M3 - Article (Academic Journal)

C2 - 16965542

SN - 1538-7933

VL - 4

SP - 2695

EP - 2703

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 12

ER -

PAR-1-dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]: evidence that pp60src does not regulate PAR-1-dependent Ca2+ entry in human platelets

Abstract

Keywords

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