Parkinson’s disease: the nutrition perspective

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease and affects ~1% of the population over the age of 60 years in industrialised countries. The aim of this review is to examine nutrition in PD across three domains: dietary intake and the development of PD; whole body metabolism in PD; and the effects of PD symptoms and treatment on nutritional status. In most cases, PD is believed to be caused by a combination of genetic and environmental factors and whilst there has been much research in the area, evidence suggests that poor dietary intake is not a risk factor for the development of PD. The evidence around body weight changes in both the prodromal and symptomatic phases of PD is inconclusive and is confounded by many factors. Malnutrition in PD has been documented as has sarcopenia, although the prevalence of the latter remains uncertain due to a lack of consensus in the definition of sarcopenia. PD symptoms, including those which are gastrointestinal and non-gastrointestinal, are known to adversely affect nutritional status. Likewise, PD treatments can cause nausea, vomiting and constipation, all of which can adversely affect nutritional status. Given that the prevalence of PD will increase as the population ages, it is important to understand the interplay between PD, comorbidities and nutritional status. Further research may contribute to the development of interventional strategies to improve symptoms, augment care, and importantly, enhance the quality of life for patients living with this complex neurodegenerative disease.
Original languageEnglish
Number of pages30
JournalProceedings of the Nutrition Society
Early online date4 Oct 2021
DOIs
Publication statusE-pub ahead of print - 4 Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 Cambridge University Press. All rights reserved.

Keywords

  • Parkinson Disease
  • Parkinsonian Disorders
  • Nutritional Status

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