Pathophysiology of the desmosome

N Cirillo

Research output: Book/ReportEdited book


Tissues are composed of cells, and one essential requirement for overall integrity is that the cells should be bound together firmly. The property that binds cells together is called cell adhesion. Many adult tissues, such as epidermis, oral mucosa, and cardiac muscle, are extremely stress-resistant. These tissues are abundantly supplied with a particular type of intercellular junction, the desmosome. Failure of desmosomal adhesion hesitates in potentially lethal diseases, be they genetic, immunological, or infectious in origin. The molecular bases and clinical relevance of desmosome-targeting diseases have been extensively reviewed in the present book
Translated title of the contributionPathophysiology of the desmosome
Original languageEnglish
PublisherResearch Signpost
ISBN (Print)8130803267
Publication statusPublished - 2009


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