Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

David T Arnold; Fergus W Hamilton; Alice Milne; Anna J Morley; Jason Viner; Marie Attwood; Alan Noel; Samuel Gunning; Jessica Hatrick; Sassa Hamilton; Karen T Elvers; Catherine Hyams; Anna Bibby; Ed Moran; Huzaifa I Adamali; James William Dodd; Nicholas A Maskell; Shaney L Barratt

doi:10.1136/thoraxjnl-2020-216086

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

David T Arnold, Fergus W Hamilton, Alice Milne, Anna J Morley, Jason Viner, Marie Attwood, Alan Noel, Samuel Gunning, Jessica Hatrick, Sassa Hamilton, Karen T Elvers, Catherine Hyams, Anna Bibby, Ed Moran, Huzaifa I Adamali, James William Dodd, Nicholas A Maskell, Shaney L Barratt

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Abstract

The longer-term consequences of SARS-CoV-2 infection are uncertain. Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study (n=163). At 8-12 weeks postadmission, survivors were invited to a systematic clinical follow-up. Of 131 participants, 110 attended the follow-up clinic. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) and limitations in reported physical ability. However, clinically significant abnormalities in chest radiograph, exercise tests, blood tests and spirometry were less frequent (35%), especially in patients not requiring supplementary oxygen during their acute infection (7%). Results suggest that a holistic approach focusing on rehabilitation and general well-being is paramount.

Original language	English
Number of pages	4
Journal	Thorax
Early online date	3 Dec 2020
DOIs	https://doi.org/10.1136/thoraxjnl-2020-216086
Publication status	E-pub ahead of print - 3 Dec 2020

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Covid19
Academic Respiratory Unit

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This is the final published version of the article (version of record). It first appeared online via BMJ Publishing Group at https://thorax.bmj.com/content/early/2020/12/02/thoraxjnl-2020-216086 . Please refer to any applicable terms of use of the publisher.
Final published version, 724 KBLicence: CC BY-NC

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An integrated epidemiological approach to understanding the relationship between lung health and multi-morbidity
Dodd, J. (Principal Investigator)
1/11/19 → 31/10/22
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Arnold, D. T., Hamilton, F. W., Milne, A., Morley, A. J., Viner, J., Attwood, M., Noel, A., Gunning, S., Hatrick, J., Hamilton, S., Elvers, K. T., Hyams, C., Bibby, A., Moran, E., Adamali, H. I., Dodd, J. W., Maskell, N. A., & Barratt, S. L. (2020). Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax. Advance online publication. https://doi.org/10.1136/thoraxjnl-2020-216086

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title = "Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort",

abstract = "The longer-term consequences of SARS-CoV-2 infection are uncertain. Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study (n=163). At 8-12 weeks postadmission, survivors were invited to a systematic clinical follow-up. Of 131 participants, 110 attended the follow-up clinic. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) and limitations in reported physical ability. However, clinically significant abnormalities in chest radiograph, exercise tests, blood tests and spirometry were less frequent (35%), especially in patients not requiring supplementary oxygen during their acute infection (7%). Results suggest that a holistic approach focusing on rehabilitation and general well-being is paramount.",

author = "Arnold, {David T} and Hamilton, {Fergus W} and Alice Milne and Morley, {Anna J} and Jason Viner and Marie Attwood and Alan Noel and Samuel Gunning and Jessica Hatrick and Sassa Hamilton and Elvers, {Karen T} and Catherine Hyams and Anna Bibby and Ed Moran and Adamali, {Huzaifa I} and Dodd, {James William} and Maskell, {Nicholas A} and Barratt, {Shaney L}",

note = "{\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2020",

month = dec,

day = "3",

doi = "10.1136/thoraxjnl-2020-216086",

language = "English",

journal = "Thorax",

issn = "0040-6376",

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Arnold, DT , Hamilton, FW, Milne, A, Morley, AJ, Viner, J, Attwood, M, Noel, A, Gunning, S, Hatrick, J, Hamilton, S, Elvers, KT, Hyams, C , Bibby, A, Moran, E, Adamali, HI, Dodd, JW, Maskell, NA & Barratt, SL 2020, 'Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort', Thorax. https://doi.org/10.1136/thoraxjnl-2020-216086

TY - JOUR

T1 - Patient outcomes after hospitalisation with COVID-19 and implications for follow-up

T2 - results from a prospective UK cohort

AU - Arnold, David T

AU - Hamilton, Fergus W

AU - Milne, Alice

AU - Morley, Anna J

AU - Viner, Jason

AU - Attwood, Marie

AU - Noel, Alan

AU - Gunning, Samuel

AU - Hatrick, Jessica

AU - Hamilton, Sassa

AU - Elvers, Karen T

AU - Hyams, Catherine

AU - Bibby, Anna

AU - Moran, Ed

AU - Adamali, Huzaifa I

AU - Dodd, James William

AU - Maskell, Nicholas A

AU - Barratt, Shaney L

PY - 2020/12/3

Y1 - 2020/12/3

N2 - The longer-term consequences of SARS-CoV-2 infection are uncertain. Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study (n=163). At 8-12 weeks postadmission, survivors were invited to a systematic clinical follow-up. Of 131 participants, 110 attended the follow-up clinic. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) and limitations in reported physical ability. However, clinically significant abnormalities in chest radiograph, exercise tests, blood tests and spirometry were less frequent (35%), especially in patients not requiring supplementary oxygen during their acute infection (7%). Results suggest that a holistic approach focusing on rehabilitation and general well-being is paramount.

AB - The longer-term consequences of SARS-CoV-2 infection are uncertain. Consecutive patients hospitalised with COVID-19 were prospectively recruited to this observational study (n=163). At 8-12 weeks postadmission, survivors were invited to a systematic clinical follow-up. Of 131 participants, 110 attended the follow-up clinic. Most (74%) had persistent symptoms (notably breathlessness and excessive fatigue) and limitations in reported physical ability. However, clinically significant abnormalities in chest radiograph, exercise tests, blood tests and spirometry were less frequent (35%), especially in patients not requiring supplementary oxygen during their acute infection (7%). Results suggest that a holistic approach focusing on rehabilitation and general well-being is paramount.

U2 - 10.1136/thoraxjnl-2020-216086

DO - 10.1136/thoraxjnl-2020-216086

M3 - Article (Academic Journal)

C2 - 33273026

SN - 0040-6376

JO - Thorax

JF - Thorax

ER -

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

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An integrated epidemiological approach to understanding the relationship between lung health and multi-morbidity

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