Projects per year
Method: We examined the association of genetic variants in PCSK9 with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in PCSK9 were used in up to 337,348 individuals.
Results: The PCSK9 allele score was associated with a lower risk of CHD, and worse log reaction time.
Conclusion: We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.
Bibliographical notePublisher Copyright:
© 2020 Termedia & Banach.
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Gaunt, L. F. & Davey Smith, G.
1/04/18 → 31/03/23