Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation

Elizabeth L. Glaisyer, Michael S. Watt, Kevin I. Booker-Milburn*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)
283 Downloads (Pure)


A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.

Original languageEnglish
Pages (from-to)5877-5880
Number of pages4
JournalOrganic Letters
Issue number18
Early online date7 Sept 2018
Publication statusPublished - 21 Sept 2018


Dive into the research topics of 'Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation'. Together they form a unique fingerprint.

Cite this