Percentage of age-predicted cardiorespiratory fitness may be a stronger risk indicator for incident type 2 diabetes than absolute levels of cardiorespiratory fitness

Setor K Kunutsor*, Hassan Khan, Samuel Seidu, Jari A Laukkanen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)
6 Downloads (Pure)

Abstract

Purpose:
There are inverse and independent associations between cardiorespiratory fitness (CRF) and several adverse cardiometabolic outcomes. The percentage of age-predicted CRF (%age-predicted CRF) is comparable to absolute CRF as a risk indicator for some of these outcomes, but the association between %age-predicted CRF and risk of type 2 diabetes (T2D) has not been previously investigated. We aimed to assess the association between %age-predicted CRF and T2D in a prospective cohort study.
Methods:
Cardiorespiratory fitness, as measured directly by peak oxygen uptake, was assessed in 1901 men aged 42-60 yr who underwent cardiopulmonary exercise testing. The age-predicted CRF estimated from a regression equation for age was converted to %age-predicted CRF using (achieved CRF/age-predicted CRF) × 100. Hazard ratios (95% CI) were estimated for T2D.
Results:
During a median follow-up of 26.8 yr, 227 T2D cases were recorded. The risk of T2D decreased continuously with increasing %age-predicted CRF ( P value for nonlinearity = .30). A 1-SD increase in %age-predicted CRF was associated with a decreased risk of T2D in analysis adjusted for established risk factors (HR = 0.68: 95% CI, 0.59-0.79). The corresponding adjusted risk was (HR = 0.51: 95% CI, 0.35-0.75) comparing extreme tertiles of %age-predicted CRF. The respective estimates for the association between absolute CRF and T2D were—HR (95% CI)—0.71 (0.60-0.83) and 0.64 (0.44-0.95).
Conclusions:
Percentage of age-predicted CRF is linearly, inversely, and independently associated with the risk of incident T2D and may be a stronger risk indicator for T2D compared to absolute CRF in a general population of middle-aged and older men.
Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Volume43
Issue number1
DOIs
Publication statusPublished - 4 Aug 2022

Bibliographical note

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Keywords

  • percentage of age-predicted cardiorespiratory fitness
  • cardiopulmonary exercise testing
  • type 2 diabetes
  • cohort study

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