Perenosins: a new class of anion transporter with anti-cancer activity

Wim Van Rossom, Daniel J Asby, Ali Tavassoli, Philip A Gale

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

Original languageEnglish
Pages (from-to)2645-50
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number9
DOIs
Publication statusPublished - 24 Feb 2016

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