Perenosins: a new class of anion transporter with anti-cancer activity

Wim Van Rossom; Daniel J Asby; Ali Tavassoli; Philip A Gale

doi:10.1039/c6ob00002a

Perenosins: a new class of anion transporter with anti-cancer activity

Wim Van Rossom, Daniel J Asby, Ali Tavassoli, Philip A Gale

Research output: Contribution to journal › Article (Academic Journal) › peer-review

47 Citations (Scopus)

Abstract

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

Original language	English
Pages (from-to)	2645-50
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	9
DOIs	https://doi.org/10.1039/c6ob00002a
Publication status	Published - 24 Feb 2016

Research Groups and Themes

Cerebrovascular and Dementia Research Group

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Perenosins: a new class of anion transporter with anti-cancer activity",

abstract = "A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.",

author = "\{Van Rossom\}, Wim and Asby, \{Daniel J\} and Ali Tavassoli and Gale, \{Philip A\}",

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journal = "Organic and Biomolecular Chemistry",

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T2 - a new class of anion transporter with anti-cancer activity

AU - Van Rossom, Wim

AU - Asby, Daniel J

AU - Tavassoli, Ali

AU - Gale, Philip A

PY - 2016/2/24

Y1 - 2016/2/24

N2 - A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

AB - A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl(-)/NO3(-) antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

U2 - 10.1039/c6ob00002a

DO - 10.1039/c6ob00002a

M3 - Article (Academic Journal)

C2 - 26905059

SN - 1477-0520

VL - 14

SP - 2645

EP - 2650

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 9

ER -

Perenosins: a new class of anion transporter with anti-cancer activity

Abstract

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UN SDGs

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