Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts

Wei-Chun Huang; Graciela B Newby; Andrew L Lewis; Peter W Stratford; Chris A Rogers; Andrew C Newby; Gavin J Murphy

doi:10.1016/j.jss.2012.11.060

Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts

Wei-Chun Huang, Graciela B Newby, Andrew L Lewis, Peter W Stratford, Chris A Rogers, Andrew C Newby, Gavin J Murphy

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Abstract

Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary vein bypass grafts. We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).

Original language	English
Pages (from-to)	33-9
Number of pages	7
Journal	Journal of Surgical Research
Volume	183
Issue number	1
DOIs	https://doi.org/10.1016/j.jss.2012.11.060
Publication status	Published - Jul 2013

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BTC (Bristol Trials Centre)
Centre for Surgical Research

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title = "Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts",

abstract = "Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary vein bypass grafts. We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).",

author = "Wei-Chun Huang and Newby, {Graciela B} and Lewis, {Andrew L} and Stratford, {Peter W} and Rogers, {Chris A} and Newby, {Andrew C} and Murphy, {Gavin J}",

year = "2013",

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doi = "10.1016/j.jss.2012.11.060",

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T1 - Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts

AU - Huang, Wei-Chun

AU - Newby, Graciela B

AU - Lewis, Andrew L

AU - Stratford, Peter W

AU - Rogers, Chris A

AU - Newby, Andrew C

AU - Murphy, Gavin J

PY - 2013/7

Y1 - 2013/7

N2 - Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary vein bypass grafts. We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).

AB - Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary vein bypass grafts. We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).

U2 - 10.1016/j.jss.2012.11.060

DO - 10.1016/j.jss.2012.11.060

M3 - Article (Academic Journal)

C2 - 23273882

SN - 1095-8673

VL - 183

SP - 33

EP - 39

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 1

ER -

Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts

Abstract

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