Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary vein bypass grafts. We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).
Bibliographical noteCopyright © 2013 Elsevier Inc. All rights reserved.
- BTC (Bristol Trials Centre)
- Centre for Surgical Research
Huang, W-C., Newby, G. B., Lewis, A. L., Stratford, P. W., Rogers, C. A., Newby, A. C., & Murphy, G. J. (2013). Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts. Journal of Surgical Research, 183(1), 33-9. https://doi.org/10.1016/j.jss.2012.11.060