Periadventitial human stem cell treatment reduces vein graft intimal thickening in pig vein-into-artery interposition grafts

Wei-Chun Huang, Graciela B Newby, Andrew L Lewis, Peter W Stratford, Chris A Rogers, Andrew C Newby, Gavin J Murphy

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Abstract

Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary vein bypass grafts. We investigated the effect on neointima formation in porcine saphenous vein grafts of periadventitial application of immortalized human mesenchymal stem cells transduced with the gene for the peptide glucagon-like peptide-1, which have been shown to induce angiogenesis in previous studies and are protected from immune-mediated destruction by encapsulation in alginate microbeads (CellBeads).
Original languageEnglish
Pages (from-to)33-9
Number of pages7
JournalJournal of Surgical Research
Volume183
Issue number1
DOIs
Publication statusPublished - Jul 2013

Bibliographical note

Copyright © 2013 Elsevier Inc. All rights reserved.

Structured keywords

  • BTC (Bristol Trials Centre)
  • Centre for Surgical Research

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