Pericytes from human veins for treatment of myocardial ischemia

Rajesh G Katare; Paolo Madeddu

doi:10.1016/j.tcm.2012.09.002

Pericytes from human veins for treatment of myocardial ischemia

Rajesh G Katare, Paolo Madeddu^*

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

19 Citations (Scopus)

Abstract

Stem cell therapies promise to regenerate the infarcted heart through the replacement of dead cardiac cells and stimulation of neovascularization. New research from our laboratory shows the transplantation of stem cells from human veins helps heart healing after an acute ischemic insult. Using a mouse model, we demonstrated that pericytes expanded from redundant human leg veins relocate around the vessels of the pen-infarct zone and release factors that promote reparative angiogenesis and cardiomyocyte survival and inhibit interstitial fibrosis. We plan to perform a first-in-man clinical trial with human pericytes in patients with refractory myocardial ischemia in the next 5 years. (C) 2013 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	66-70
Number of pages	5
Journal	Trends in Cardiovascular Medicine
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.tcm.2012.09.002
Publication status	Published - Apr 2013

Bibliographical note

Keywords

STEM-CELLS
CARDIAC REPAIR
GENE-THERAPY
ANGIOGENESIS
PROGENITORS
HEART
AORTA
VASCULOGENESIS
ACTIVATION
GROWTH

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title = "Pericytes from human veins for treatment of myocardial ischemia",

abstract = "Stem cell therapies promise to regenerate the infarcted heart through the replacement of dead cardiac cells and stimulation of neovascularization. New research from our laboratory shows the transplantation of stem cells from human veins helps heart healing after an acute ischemic insult. Using a mouse model, we demonstrated that pericytes expanded from redundant human leg veins relocate around the vessels of the pen-infarct zone and release factors that promote reparative angiogenesis and cardiomyocyte survival and inhibit interstitial fibrosis. We plan to perform a first-in-man clinical trial with human pericytes in patients with refractory myocardial ischemia in the next 5 years. (C) 2013 Elsevier Inc. All rights reserved.",

keywords = "STEM-CELLS, CARDIAC REPAIR, GENE-THERAPY, ANGIOGENESIS, PROGENITORS, HEART, AORTA, VASCULOGENESIS, ACTIVATION, GROWTH",

author = "Katare, {Rajesh G} and Paolo Madeddu",

year = "2013",

month = apr,

doi = "10.1016/j.tcm.2012.09.002",

language = "English",

volume = "23",

pages = "66--70",

journal = "Trends in Cardiovascular Medicine",

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TY - JOUR

T1 - Pericytes from human veins for treatment of myocardial ischemia

AU - Katare, Rajesh G

AU - Madeddu, Paolo

PY - 2013/4

Y1 - 2013/4

N2 - Stem cell therapies promise to regenerate the infarcted heart through the replacement of dead cardiac cells and stimulation of neovascularization. New research from our laboratory shows the transplantation of stem cells from human veins helps heart healing after an acute ischemic insult. Using a mouse model, we demonstrated that pericytes expanded from redundant human leg veins relocate around the vessels of the pen-infarct zone and release factors that promote reparative angiogenesis and cardiomyocyte survival and inhibit interstitial fibrosis. We plan to perform a first-in-man clinical trial with human pericytes in patients with refractory myocardial ischemia in the next 5 years. (C) 2013 Elsevier Inc. All rights reserved.

AB - Stem cell therapies promise to regenerate the infarcted heart through the replacement of dead cardiac cells and stimulation of neovascularization. New research from our laboratory shows the transplantation of stem cells from human veins helps heart healing after an acute ischemic insult. Using a mouse model, we demonstrated that pericytes expanded from redundant human leg veins relocate around the vessels of the pen-infarct zone and release factors that promote reparative angiogenesis and cardiomyocyte survival and inhibit interstitial fibrosis. We plan to perform a first-in-man clinical trial with human pericytes in patients with refractory myocardial ischemia in the next 5 years. (C) 2013 Elsevier Inc. All rights reserved.

KW - STEM-CELLS

KW - CARDIAC REPAIR

KW - GENE-THERAPY

KW - ANGIOGENESIS

KW - PROGENITORS

KW - HEART

KW - AORTA

KW - VASCULOGENESIS

KW - ACTIVATION

KW - GROWTH

U2 - 10.1016/j.tcm.2012.09.002

DO - 10.1016/j.tcm.2012.09.002

M3 - Review article (Academic Journal)

C2 - 23313330

VL - 23

SP - 66

EP - 70

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

SN - 1050-1738

IS - 3

ER -

Pericytes from human veins for treatment of myocardial ischemia

Abstract

Bibliographical note

Keywords

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