Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder

Fahd Baig, Michael Lawton, Michal Rolinski, Claudio Ruffmann, Johannes C Klein, Yoav Ben-Shlomo, Kannan Nithi, Okai David, Michele Hu

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)
262 Downloads (Pure)

Abstract

AbstractIntroduction Changes in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction. Methods 941 population-ascertained PD subjects within 3.5 years of diagnosis, 128 patients with rapid eye movement sleep behaviour disorder (RBD) and 292 control subjects were fully characterised for motor symptoms, non-motor symptoms and across the following 5 personality domains: 1) neuroticism 2) extraversion 3) conscientiousness 4) agreeableness 5) openness using the Big Five Inventory. Results Patients with early PD were more neurotic (p < 0.001), less extraverted (p < 0.001) and less open than controls (p < 0.001). RBD subjects showed the same pattern of being more neurotic (p < 0.001), less extraverted (p = 0.03) and less open (p < 0.001). PD patients had smoked less (p = 0.02) and drunk less alcohol (p = 0.03) than controls, but caffeine beverage consumption was similar. Being more extraverted (p < 0.001), more open (p < 0.001), and less neurotic (p < 0.001) predicted higher alcohol use, while being more extravert (p = 0.007) and less agreeable (p < 0.001) was associated with smoking more. Conclusions A similar pattern of personality changes is seen in PD and RBD compared to a control population. Personality characteristics were associated with addictive behaviours, suggestive of a common link, but the lower rates of addictive behaviours before and after the onset of motor symptoms in PD persisted after accounting for personality.
Original languageEnglish
Pages (from-to)72-78
Number of pages7
JournalParkinsonism and Related Disorders
Volume37
Early online date1 Feb 2017
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Parkinson's disease
  • Personality
  • Addiction
  • REM sleep behaviour disorder
  • Smoking

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