Skip to content

Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers

Research output: Contribution to journalArticle

Standard

Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers. / Connelly, Jessica J.; Golding, Jean; Gregory, Steve P; Ring, Susan M.; Davis, John M.; Smith, George Davey; Harris, James C.; Carter, C. Sue; Pembrey, Marcus.

In: PLoS ONE, Vol. 9, No. 3, e90465, 12.03.2014.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Connelly, Jessica J. ; Golding, Jean ; Gregory, Steve P ; Ring, Susan M. ; Davis, John M. ; Smith, George Davey ; Harris, James C. ; Carter, C. Sue ; Pembrey, Marcus. / Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers. In: PLoS ONE. 2014 ; Vol. 9, No. 3.

Bibtex

@article{9fc8741fe0ce4344af84d1aeef8484ad,
title = "Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers",
abstract = "Background It is assumed that the oxytocin receptor gene (OXTR) is associated with factors that are related to features of reproduction as well as the currently emerging fields of mood and emotional response. Methods We analysed data from over 8000 mothers who participated in the Avon Longitudinal Study of Parents and Children (ALSPAC). We determined reproductive, emotional and personality differences related to the two SNPs rs53576 and rs2254298 of the oxytocin receptor gene to determine whether there was evidence in this population for: (i) associations with emotional and personality differences, and (ii) behavioural or environmental links with these SNPs using a hypothesis free approach with over 1000 types of exposure. Results Our analyses of 7723 women showed that there were no differences in 11 mood, social or relationship characteristics associated with the rs2254298, and just one with rs53576 (with emotional loneliness) – one statistically significant out of 22 tests is no more than would be expected by chance. There were no interactions with childhood abuse. Using a hypothesis-free approach we found few indicators of environmental or behavioural differences associated with rs2254298, but there was an excess of associations with eating habits with rs53576. The findings included an association with dieting to lose weight, and habits typical of bulimia for the women with GG. The nutrition of the women also showed negative associations of the GG genotype with 13 nutrients, including vitamins D, B12 and retinol, and intake of calcium, potassium and iodine. Conclusions We conclude that this large database of pregnant women was unable to provide confirmation of the types of personality associated with these two OXTR SNPs, but we have shown some evidence of eating differences in those with GG on rs53576. Confirmation of our hypothesis free associations using other data sets is important.",
author = "Connelly, {Jessica J.} and Jean Golding and Gregory, {Steve P} and Ring, {Susan M.} and Davis, {John M.} and Smith, {George Davey} and Harris, {James C.} and Carter, {C. Sue} and Marcus Pembrey",
year = "2014",
month = "3",
day = "12",
doi = "10.1371/journal.pone.0090465",
language = "English",
volume = "9",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Personality, Behavior and Environmental Features Associated with OXTR Genetic Variants in British Mothers

AU - Connelly, Jessica J.

AU - Golding, Jean

AU - Gregory, Steve P

AU - Ring, Susan M.

AU - Davis, John M.

AU - Smith, George Davey

AU - Harris, James C.

AU - Carter, C. Sue

AU - Pembrey, Marcus

PY - 2014/3/12

Y1 - 2014/3/12

N2 - Background It is assumed that the oxytocin receptor gene (OXTR) is associated with factors that are related to features of reproduction as well as the currently emerging fields of mood and emotional response. Methods We analysed data from over 8000 mothers who participated in the Avon Longitudinal Study of Parents and Children (ALSPAC). We determined reproductive, emotional and personality differences related to the two SNPs rs53576 and rs2254298 of the oxytocin receptor gene to determine whether there was evidence in this population for: (i) associations with emotional and personality differences, and (ii) behavioural or environmental links with these SNPs using a hypothesis free approach with over 1000 types of exposure. Results Our analyses of 7723 women showed that there were no differences in 11 mood, social or relationship characteristics associated with the rs2254298, and just one with rs53576 (with emotional loneliness) – one statistically significant out of 22 tests is no more than would be expected by chance. There were no interactions with childhood abuse. Using a hypothesis-free approach we found few indicators of environmental or behavioural differences associated with rs2254298, but there was an excess of associations with eating habits with rs53576. The findings included an association with dieting to lose weight, and habits typical of bulimia for the women with GG. The nutrition of the women also showed negative associations of the GG genotype with 13 nutrients, including vitamins D, B12 and retinol, and intake of calcium, potassium and iodine. Conclusions We conclude that this large database of pregnant women was unable to provide confirmation of the types of personality associated with these two OXTR SNPs, but we have shown some evidence of eating differences in those with GG on rs53576. Confirmation of our hypothesis free associations using other data sets is important.

AB - Background It is assumed that the oxytocin receptor gene (OXTR) is associated with factors that are related to features of reproduction as well as the currently emerging fields of mood and emotional response. Methods We analysed data from over 8000 mothers who participated in the Avon Longitudinal Study of Parents and Children (ALSPAC). We determined reproductive, emotional and personality differences related to the two SNPs rs53576 and rs2254298 of the oxytocin receptor gene to determine whether there was evidence in this population for: (i) associations with emotional and personality differences, and (ii) behavioural or environmental links with these SNPs using a hypothesis free approach with over 1000 types of exposure. Results Our analyses of 7723 women showed that there were no differences in 11 mood, social or relationship characteristics associated with the rs2254298, and just one with rs53576 (with emotional loneliness) – one statistically significant out of 22 tests is no more than would be expected by chance. There were no interactions with childhood abuse. Using a hypothesis-free approach we found few indicators of environmental or behavioural differences associated with rs2254298, but there was an excess of associations with eating habits with rs53576. The findings included an association with dieting to lose weight, and habits typical of bulimia for the women with GG. The nutrition of the women also showed negative associations of the GG genotype with 13 nutrients, including vitamins D, B12 and retinol, and intake of calcium, potassium and iodine. Conclusions We conclude that this large database of pregnant women was unable to provide confirmation of the types of personality associated with these two OXTR SNPs, but we have shown some evidence of eating differences in those with GG on rs53576. Confirmation of our hypothesis free associations using other data sets is important.

U2 - 10.1371/journal.pone.0090465

DO - 10.1371/journal.pone.0090465

M3 - Article

C2 - 24621820

VL - 9

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

M1 - e90465

ER -