PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

Brunela Pitanga Madureira; Fernanda Marques de Carvalho; Maria Cristina Pessolani; Simon Michael Collin; Patrícia Duarte Deps

doi:10.1016/j.imbio.2019.11.001

PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

Brunela Pitanga Madureira, Fernanda Marques de Carvalho, Maria Cristina Pessolani, Simon Michael Collin, Patrícia Duarte Deps

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal)

Abstract

Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.

Original language	English
Pages (from-to)	151866
Journal	Immunobiology
Early online date	10 Nov 2019
DOIs	https://doi.org/10.1016/j.imbio.2019.11.001
Publication status	E-pub ahead of print - 10 Nov 2019

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Madureira, B. P., de Carvalho, F. M., Pessolani, M. C., Collin, S. M., & Deps, P. D. (2019). PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil. Immunobiology, 151866. https://doi.org/10.1016/j.imbio.2019.11.001

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title = "PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil",

abstract = "Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.",

author = "Madureira, {Brunela Pitanga} and {de Carvalho}, {Fernanda Marques} and Pessolani, {Maria Cristina} and Collin, {Simon Michael} and Deps, {Patr{\'i}cia Duarte}",

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doi = "10.1016/j.imbio.2019.11.001",

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PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil. / Madureira, Brunela Pitanga; de Carvalho, Fernanda Marques; Pessolani, Maria Cristina; Collin, Simon Michael; Deps, Patrícia Duarte.

In: Immunobiology, 10.11.2019, p. 151866.

Research output: Contribution to journal › Article (Academic Journal)

TY - JOUR

T1 - PGL-1 and LID-1 antibody levels in HIV-infected and HIV-uninfected individuals in a Hansen's disease (leprosy) endemic area of Brazil

AU - Madureira, Brunela Pitanga

AU - de Carvalho, Fernanda Marques

AU - Pessolani, Maria Cristina

AU - Collin, Simon Michael

AU - Deps, Patrícia Duarte

PY - 2019/11/10

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AB - Serological tests for subclinical Mycobacterium leprae infection based on antibodies to phenolic glycolipid-1 (PGL-1) and leprosy IDRI diagnostic-1 (LID-1) have not been compared in HIV-infected and uninfected individuals. PGL-1 seropositivity by ELISA was 6.0 % (21/350) in HIV-infected compared with 29.1 % (102/350) in HIV-uninfected individuals (p < 0.001); LID-1 seropositivity was 45.4 % (159/350) in HIV-infected compared with 50.3 % (153/304) in HIV-uninfected individuals (p = 0.21). In HIV-infected individuals, LID-1 but not PGL-1 antibody levels were inversely associated with CD4+ cell count (p = 0.02). These differential associations of HIV infection and CD4 count with PGL-1 and LID-1 have implications for M leprae immunodiagnostic tools and require replication.

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