The endo-lysosomal system is an interconnected tubulo-vesicular network that acts as a sorting station to process and distribute internalised cargo. This network accepts cargoes from both the plasma membrane and the biosynthetic pathway, and directs these cargos either towards the lysosome for degradation, the peri-nuclear recycling endosome for return to the cell surface, or to the trans-Golgi network. These intracellular membranes are variously enriched in different phosphoinositides that help to shape compartmental identity. These lipids act to localise a number of phosphoinositide-binding proteins that function as sorting machineries to regulate endosomal cargo sorting. Herein we discuss regulation of these machineries by phosphorinositides adn explore how phosphoinositide-switching contributes towards sorting decisions made at this platform.
|Translated title of the contribution||Phosphoinositides in Mammalian Endo-Iysosomal Network|
|Title of host publication||Phosphoinositides II: The Diverse Biological Functions: Subcellular Biochemistry|
|Editors||T Balla, JD York, M Wymann|
|Pages||65 - 110|
|Number of pages||46|
|Publication status||Published - 2012|