Phosphoinositides in Mammalian Endo-Iysosomal Network

PJ Cullen, JG Carlton

Research output: Chapter in Book/Report/Conference proceedingChapter in a book


The endo-lysosomal system is an interconnected tubulo-vesicular network that acts as a sorting station to process and distribute internalised cargo. This network accepts cargoes from both the plasma membrane and the biosynthetic pathway, and directs these cargos either towards the lysosome for degradation, the peri-nuclear recycling endosome for return to the cell surface, or to the trans-Golgi network. These intracellular membranes are variously enriched in different phosphoinositides that help to shape compartmental identity. These lipids act to localise a number of phosphoinositide-binding proteins that function as sorting machineries to regulate endosomal cargo sorting. Herein we discuss regulation of these machineries by phosphorinositides adn explore how phosphoinositide-switching contributes towards sorting decisions made at this platform.
Translated title of the contributionPhosphoinositides in Mammalian Endo-Iysosomal Network
Original languageEnglish
Title of host publicationPhosphoinositides II: The Diverse Biological Functions: Subcellular Biochemistry
EditorsT Balla, JD York, M Wymann
PublisherSpringer Netherlands
Pages65 - 110
Number of pages46
ISBN (Print)9789400730144
Publication statusPublished - 2012

Bibliographical note

Other: Chapter 3


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