Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

Nikos Papadimitriou; Niki L Dimou; Konstantinos K Tsilidis; Barbara Banbury; Richard M Martin; Sarah J Lewis; Nabila Kazmi; Timothy M Robinson; Demetrius Albanes; Krasimira Aleksandrova; Sonja I Berndt; Timothy D Bishop; Hermann Brenner; Daniel D. Buchanan; H. Bas Bueno-de-Mesquita; Peter T. Campbell; Sergi Castellví-Bel; Andrew T. Chan; Jenny Chang-Claude; Merete Ellingjord-Dale; Jane C. Figueiredo; Steven Gallinger; Graham G. Giles; Edward Giovannucci; Stephen B. Gruber; Andrea Gsur; Jochen Hampe; Heather Hampel; Sophia Harlid; Tabitha A Harrison; Michael Hoffmeister; John L Hopper; Li Hsu; Jose-Maria Huerta; Jeroen R Huyghe; Mark A. Jenkins; Temitope O Keku; Tilman Kühn; Carlo La Vecchia; Loic Le Marchand; Christopher Li; Li Li; Annika Lindblom; Noralane M. Lindor; Brigid Lynch; Sanford  Markowitz; Giovanna Masala; Anna May; Roger L Milne; Evelyn  Monninkhof; Lorena  Moreno; Victor Moreno; Polly Newcomb; Kenneth Offit; Vittorio Perduca; Paul Pharoah; Elizabeth A. Platz; John D Potter; Gad Rennert; Elio Riboli; Maria-Jose Sanchez; Stephanie L. Schmit; Robert E Schoen; Gianluca Severi; Sabina Sieri; Martha L. Slattery; Mingyang Song; Catherine M. Tangen; Stephen Thibodeau; Ruth C Travis; Antonia Trichopoulou; Cornelia M Ulrich; Franzel Jb van Duijnhoven; Bethany Van Guelpen; Pavel Vodicka; Emily White; Alicja Wolk; Michael Woods; Anna H. Wu; Ulrike Peters; Marc J Gunter; Neil Murphy

doi:10.1038/s41467-020-14389-8

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

Nikos Papadimitriou, Niki L Dimou, Konstantinos K Tsilidis, Barbara Banbury, Richard M Martin, Sarah J Lewis, Nabila Kazmi, Timothy M Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I Berndt, Timothy D Bishop, Hermann Brenner, Daniel D. Buchanan, H. Bas Bueno-de-Mesquita, Peter T. Campbell, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Merete Ellingjord-DaleJane C. Figueiredo, Steven Gallinger, Graham G. Giles, Edward Giovannucci, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A Harrison, Michael Hoffmeister, John L Hopper, Li Hsu, Jose-Maria Huerta, Jeroen R Huyghe, Mark A. Jenkins, Temitope O Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher Li, Li Li, Annika Lindblom, Noralane M. Lindor, Brigid Lynch, Sanford Markowitz, Giovanna Masala, Anna May, Roger L Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly Newcomb, Kenneth Offit, Vittorio Perduca, Paul Pharoah, Elizabeth A. Platz, John D Potter, Gad Rennert, Elio Riboli, Maria-Jose Sanchez, Stephanie L. Schmit, Robert E Schoen, Gianluca Severi, Sabina Sieri, Martha L. Slattery, Mingyang Song, Catherine M. Tangen, Stephen Thibodeau, Ruth C Travis, Antonia Trichopoulou , Cornelia M Ulrich, Franzel Jb van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael Woods, Anna H. Wu, Ulrike Peters, Marc J Gunter, Neil Murphy

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Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

Original language	English
Article number	597 (2020)
Number of pages	10
Journal	Nature Communications
Volume	11
DOIs	https://doi.org/10.1038/s41467-020-14389-8
Publication status	Published - 30 Jan 2020

Research Groups and Themes

ICEP

Keywords

breast cancer
cancer
Cancer epidemiology
cancer genetics
colorectal cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Papadimitriou, N., Dimou, N. L., Tsilidis, K. K., Banbury, B., Martin, R. M., Lewis, S. J., Kazmi, N., Robinson, T. M., Albanes, D., Aleksandrova, K., Berndt, S. I., Bishop, T. D., Brenner, H., Buchanan, D. D., Bueno-de-Mesquita, H. B., Campbell, P. T., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., ... Murphy, N. (2020). Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis. Nature Communications, 11, Article 597 (2020). https://doi.org/10.1038/s41467-020-14389-8

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title = "Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis",

abstract = "Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.",

keywords = "breast cancer, cancer, Cancer epidemiology, cancer genetics, colorectal cancer",

author = "Nikos Papadimitriou and Dimou, {Niki L} and Tsilidis, {Konstantinos K} and Barbara Banbury and Martin, {Richard M} and Lewis, {Sarah J} and Nabila Kazmi and Robinson, {Timothy M} and Demetrius Albanes and Krasimira Aleksandrova and Berndt, {Sonja I} and Bishop, {Timothy D} and Hermann Brenner and Buchanan, {Daniel D.} and Bueno-de-Mesquita, {H. Bas} and Campbell, {Peter T.} and Sergi Castellv{\'i}-Bel and Chan, {Andrew T.} and Jenny Chang-Claude and Merete Ellingjord-Dale and Figueiredo, {Jane C.} and Steven Gallinger and Giles, {Graham G.} and Edward Giovannucci and Gruber, {Stephen B.} and Andrea Gsur and Jochen Hampe and Heather Hampel and Sophia Harlid and Harrison, {Tabitha A} and Michael Hoffmeister and Hopper, {John L} and Li Hsu and Jose-Maria Huerta and Huyghe, {Jeroen R} and Jenkins, {Mark A.} and Keku, {Temitope O} and Tilman K{\"u}hn and {La Vecchia}, Carlo and {Le Marchand}, Loic and Christopher Li and Li Li and Annika Lindblom and Lindor, {Noralane M.} and Brigid Lynch and Sanford Markowitz and Giovanna Masala and Anna May and Milne, {Roger L} and Evelyn Monninkhof and Lorena Moreno and Victor Moreno and Polly Newcomb and Kenneth Offit and Vittorio Perduca and Paul Pharoah and Platz, {Elizabeth A.} and Potter, {John D} and Gad Rennert and Elio Riboli and Maria-Jose Sanchez and Schmit, {Stephanie L.} and Schoen, {Robert E} and Gianluca Severi and Sabina Sieri and Slattery, {Martha L.} and Mingyang Song and Tangen, {Catherine M.} and Stephen Thibodeau and Travis, {Ruth C} and Antonia Trichopoulou and Ulrich, {Cornelia M} and {van Duijnhoven}, {Franzel Jb} and {Van Guelpen}, Bethany and Pavel Vodicka and Emily White and Alicja Wolk and Michael Woods and Wu, {Anna H.} and Ulrike Peters and Gunter, {Marc J} and Neil Murphy",

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Papadimitriou, N, Dimou, NL, Tsilidis, KK, Banbury, B, Martin, RM , Lewis, SJ, Kazmi, N, Robinson, TM, Albanes, D, Aleksandrova, K, Berndt, SI, Bishop, TD, Brenner, H, Buchanan, DD, Bueno-de-Mesquita, HB, Campbell, PT, Castellví-Bel, S, Chan, AT, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, JC, Gallinger, S, Giles, GG, Giovannucci, E, Gruber, SB, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, TA, Hoffmeister, M, Hopper, JL, Hsu, L, Huerta, J-M, Huyghe, JR, Jenkins, MA, Keku, TO, Kühn, T, La Vecchia, C, Le Marchand, L, Li, C, Li, L, Lindblom, A, Lindor, NM, Lynch, B, Markowitz, S, Masala, G, May, A, Milne, RL, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, P, Offit, K, Perduca, V, Pharoah, P, Platz, EA, Potter, JD, Rennert, G, Riboli, E, Sanchez, M-J, Schmit, SL, Schoen, RE, Severi, G, Sieri, S, Slattery, ML, Song, M, Tangen, CM, Thibodeau, S, Travis, RC, Trichopoulou , A, Ulrich, CM, van Duijnhoven, FJ, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, M, Wu, AH, Peters, U, Gunter, MJ & Murphy, N 2020, 'Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis', Nature Communications, vol. 11, 597 (2020). https://doi.org/10.1038/s41467-020-14389-8

TY - JOUR

T1 - Physical activity and risks of breast and colorectal cancer

T2 - A Mendelian randomization analysis

AU - Papadimitriou, Nikos

AU - Dimou, Niki L

AU - Tsilidis, Konstantinos K

AU - Banbury, Barbara

AU - Martin, Richard M

AU - Lewis, Sarah J

AU - Kazmi, Nabila

AU - Robinson, Timothy M

AU - Albanes, Demetrius

AU - Aleksandrova, Krasimira

AU - Berndt, Sonja I

AU - Bishop, Timothy D

AU - Brenner, Hermann

AU - Buchanan, Daniel D.

AU - Bueno-de-Mesquita, H. Bas

AU - Campbell, Peter T.

AU - Castellví-Bel, Sergi

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Ellingjord-Dale, Merete

AU - Figueiredo, Jane C.

AU - Gallinger, Steven

AU - Giles, Graham G.

AU - Giovannucci, Edward

AU - Gruber, Stephen B.

AU - Gsur, Andrea

AU - Hampe, Jochen

AU - Hampel, Heather

AU - Harlid, Sophia

AU - Harrison, Tabitha A

AU - Hoffmeister, Michael

AU - Hopper, John L

AU - Hsu, Li

AU - Huerta, Jose-Maria

AU - Huyghe, Jeroen R

AU - Jenkins, Mark A.

AU - Keku, Temitope O

AU - Kühn, Tilman

AU - La Vecchia, Carlo

AU - Le Marchand, Loic

AU - Li, Christopher

AU - Li, Li

AU - Lindblom, Annika

AU - Lindor, Noralane M.

AU - Lynch, Brigid

AU - Markowitz, Sanford

AU - Masala, Giovanna

AU - May, Anna

AU - Milne, Roger L

AU - Monninkhof, Evelyn

AU - Moreno, Lorena

AU - Moreno, Victor

AU - Newcomb, Polly

AU - Offit, Kenneth

AU - Perduca, Vittorio

AU - Pharoah, Paul

AU - Platz, Elizabeth A.

AU - Potter, John D

AU - Rennert, Gad

AU - Riboli, Elio

AU - Sanchez, Maria-Jose

AU - Schmit, Stephanie L.

AU - Schoen, Robert E

AU - Severi, Gianluca

AU - Sieri, Sabina

AU - Slattery, Martha L.

AU - Song, Mingyang

AU - Tangen, Catherine M.

AU - Thibodeau, Stephen

AU - Travis, Ruth C

AU - Trichopoulou , Antonia

AU - Ulrich, Cornelia M

AU - van Duijnhoven, Franzel Jb

AU - Van Guelpen, Bethany

AU - Vodicka, Pavel

AU - White, Emily

AU - Wolk, Alicja

AU - Woods, Michael

AU - Wu, Anna H.

AU - Peters, Ulrike

AU - Gunter, Marc J

AU - Murphy, Neil

PY - 2020/1/30

Y1 - 2020/1/30

N2 - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

AB - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

KW - breast cancer

KW - cancer

KW - Cancer epidemiology

KW - cancer genetics

KW - colorectal cancer

UR - http://www.scopus.com/inward/record.url?scp=85078709648&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-14389-8

DO - 10.1038/s41467-020-14389-8

M3 - Article (Academic Journal)

C2 - 32001714

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

M1 - 597 (2020)

ER -

Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

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Physical activity and risks of breast and colorectal cancer: A Mendelian randomization analysis

Abstract

Research Groups and Themes

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UN SDGs

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Professor Sarah J Lewis

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