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Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators

Research output: Contribution to journalReview article

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Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators. / Bates, Dave O; Beazley-Long, Nick; Benest, Andrew; Ye, Xi; Ved, Nikki; Hulse, Richard; Barratt, Shaney; Machado, Maria; Donaldson, Lucy F; Harper, Steven; Peiris-Pages, Maria; Tortonese, Domingo; Oltean, Sebastian; Foster, Rebecca R.

In: Comprehensive Physiology, Vol. 8, No. 3, 18.06.2018, p. 955-979.

Research output: Contribution to journalReview article

Harvard

Bates, DO, Beazley-Long, N, Benest, A, Ye, X, Ved, N, Hulse, R, Barratt, S, Machado, M, Donaldson, LF, Harper, S, Peiris-Pages, M, Tortonese, D, Oltean, S & Foster, RR 2018, 'Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators', Comprehensive Physiology, vol. 8, no. 3, pp. 955-979. https://doi.org/10.1002/cphy.c170015

APA

Bates, D. O., Beazley-Long, N., Benest, A., Ye, X., Ved, N., Hulse, R., ... Foster, R. R. (2018). Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators. Comprehensive Physiology, 8(3), 955-979. https://doi.org/10.1002/cphy.c170015

Vancouver

Bates DO, Beazley-Long N, Benest A, Ye X, Ved N, Hulse R et al. Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators. Comprehensive Physiology. 2018 Jun 18;8(3):955-979. https://doi.org/10.1002/cphy.c170015

Author

Bates, Dave O ; Beazley-Long, Nick ; Benest, Andrew ; Ye, Xi ; Ved, Nikki ; Hulse, Richard ; Barratt, Shaney ; Machado, Maria ; Donaldson, Lucy F ; Harper, Steven ; Peiris-Pages, Maria ; Tortonese, Domingo ; Oltean, Sebastian ; Foster, Rebecca R. / Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators. In: Comprehensive Physiology. 2018 ; Vol. 8, No. 3. pp. 955-979.

Bibtex

@article{edd25f262e264d489317507313a436d6,
title = "Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators",
abstract = "The vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through their actions on vascular cells, but also through direct actions on other tissue types, including epithelial cells, neurons, and the immune system. The complexity of the five members of the gene family in terms of their different splice isoforms, differential translation, and specific localizations have enabled tissues to use these potent signaling molecules to control how they function to maintain their environment. This homeostatic function of VEGFs has been less intensely studied than their involvement in disease processes, development, and reproduction, but they still play a substantial and significant role in healthy control of blood volume and pressure, interstitial volume and drainage, renal and lung function, immunity, and signal processing in the peripheral and central nervous system. The widespread expression of VEGFs in healthy adult tissues, and the disturbances seen when VEGF signaling is inhibited support this view of the proteins as endogenous regulators of normal physiological function. This review summarizes the evidence and recent breakthroughs in understanding of the physiology that is regulated by VEGF, with emphasis on the role they play in maintaining homeostasis.",
author = "Bates, {Dave O} and Nick Beazley-Long and Andrew Benest and Xi Ye and Nikki Ved and Richard Hulse and Shaney Barratt and Maria Machado and Donaldson, {Lucy F} and Steven Harper and Maria Peiris-Pages and Domingo Tortonese and Sebastian Oltean and Foster, {Rebecca R}",
year = "2018",
month = "6",
day = "18",
doi = "10.1002/cphy.c170015",
language = "English",
volume = "8",
pages = "955--979",
journal = "Comprehensive Physiology",
issn = "2040-4603",
publisher = "John Wiley & Sons, Inc",
number = "3",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators

AU - Bates, Dave O

AU - Beazley-Long, Nick

AU - Benest, Andrew

AU - Ye, Xi

AU - Ved, Nikki

AU - Hulse, Richard

AU - Barratt, Shaney

AU - Machado, Maria

AU - Donaldson, Lucy F

AU - Harper, Steven

AU - Peiris-Pages, Maria

AU - Tortonese, Domingo

AU - Oltean, Sebastian

AU - Foster, Rebecca R

PY - 2018/6/18

Y1 - 2018/6/18

N2 - The vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through their actions on vascular cells, but also through direct actions on other tissue types, including epithelial cells, neurons, and the immune system. The complexity of the five members of the gene family in terms of their different splice isoforms, differential translation, and specific localizations have enabled tissues to use these potent signaling molecules to control how they function to maintain their environment. This homeostatic function of VEGFs has been less intensely studied than their involvement in disease processes, development, and reproduction, but they still play a substantial and significant role in healthy control of blood volume and pressure, interstitial volume and drainage, renal and lung function, immunity, and signal processing in the peripheral and central nervous system. The widespread expression of VEGFs in healthy adult tissues, and the disturbances seen when VEGF signaling is inhibited support this view of the proteins as endogenous regulators of normal physiological function. This review summarizes the evidence and recent breakthroughs in understanding of the physiology that is regulated by VEGF, with emphasis on the role they play in maintaining homeostasis.

AB - The vascular endothelial growth factor (VEGF) family of proteins are key regulators of physiological systems. Originally linked with endothelial function, they have since become understood to be principal regulators of multiple tissues, both through their actions on vascular cells, but also through direct actions on other tissue types, including epithelial cells, neurons, and the immune system. The complexity of the five members of the gene family in terms of their different splice isoforms, differential translation, and specific localizations have enabled tissues to use these potent signaling molecules to control how they function to maintain their environment. This homeostatic function of VEGFs has been less intensely studied than their involvement in disease processes, development, and reproduction, but they still play a substantial and significant role in healthy control of blood volume and pressure, interstitial volume and drainage, renal and lung function, immunity, and signal processing in the peripheral and central nervous system. The widespread expression of VEGFs in healthy adult tissues, and the disturbances seen when VEGF signaling is inhibited support this view of the proteins as endogenous regulators of normal physiological function. This review summarizes the evidence and recent breakthroughs in understanding of the physiology that is regulated by VEGF, with emphasis on the role they play in maintaining homeostasis.

U2 - 10.1002/cphy.c170015

DO - 10.1002/cphy.c170015

M3 - Review article

C2 - 29978898

VL - 8

SP - 955

EP - 979

JO - Comprehensive Physiology

JF - Comprehensive Physiology

SN - 2040-4603

IS - 3

ER -