Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity

Syed Hamid Hussain*, Abdul Latif, Russell J. Cox, Thomas J. Simpson, Mumtaz Ali, Mohammad Arfan, Ghias Uddin

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)

Abstract

Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-beta-D-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 mu m, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalPhytochemistry letters
Volume7
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Ligularia thomsonii
  • Phenylpropanoid glucosides
  • Antioxidant activity
  • BISABOLANE SESQUITERPENES
  • ANTIOXIDANT
  • ACID
  • IDENTIFICATION
  • CHROMATOGRAPHY
  • JAPONICA
  • NMR

Cite this