Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity

Syed Hamid Hussain; Abdul Latif; Russell J. Cox; Thomas J. Simpson; Mumtaz Ali; Mohammad Arfan; Ghias Uddin

doi:10.1016/j.phytol.2013.09.002

Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity

Syed Hamid Hussain^*, Abdul Latif, Russell J. Cox, Thomas J. Simpson, Mumtaz Ali, Mohammad Arfan, Ghias Uddin

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-beta-D-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 mu m, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	6-10
Number of pages	5
Journal	Phytochemistry letters
Volume	7
DOIs	https://doi.org/10.1016/j.phytol.2013.09.002
Publication status	Published - Feb 2014

Keywords

Ligularia thomsonii
Phenylpropanoid glucosides
Antioxidant activity
BISABOLANE SESQUITERPENES
ANTIOXIDANT
ACID
IDENTIFICATION
CHROMATOGRAPHY
JAPONICA
NMR

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Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
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A 500MHZ NMR SPECTROMETER TO UNDERPIN CHEMICAL RESEARCH AT BRISTOL
Simpson, T. J. (Principal Investigator)
1/09/07 → 1/09/10
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@article{b6bfe567e0a441b8ab5fd86e441c1068,

title = "Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity",

abstract = "Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-beta-D-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 mu m, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.",

keywords = "Ligularia thomsonii, Phenylpropanoid glucosides, Antioxidant activity, BISABOLANE SESQUITERPENES, ANTIOXIDANT, ACID, IDENTIFICATION, CHROMATOGRAPHY, JAPONICA, NMR",

author = "Hussain, {Syed Hamid} and Abdul Latif and Cox, {Russell J.} and Simpson, {Thomas J.} and Mumtaz Ali and Mohammad Arfan and Ghias Uddin",

year = "2014",

month = feb,

doi = "10.1016/j.phytol.2013.09.002",

language = "English",

volume = "7",

pages = "6--10",

journal = "Phytochemistry letters",

issn = "1874-3900",

publisher = "Amsterdam:Elsevier",

}

TY - JOUR

T1 - Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity

AU - Hussain, Syed Hamid

AU - Latif, Abdul

AU - Cox, Russell J.

AU - Simpson, Thomas J.

AU - Ali, Mumtaz

AU - Arfan, Mohammad

AU - Uddin, Ghias

PY - 2014/2

Y1 - 2014/2

N2 - Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-beta-D-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 mu m, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

AB - Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-beta-D-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 mu m, respectively. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

KW - Ligularia thomsonii

KW - Phenylpropanoid glucosides

KW - Antioxidant activity

KW - BISABOLANE SESQUITERPENES

KW - ANTIOXIDANT

KW - ACID

KW - IDENTIFICATION

KW - CHROMATOGRAPHY

KW - JAPONICA

KW - NMR

U2 - 10.1016/j.phytol.2013.09.002

DO - 10.1016/j.phytol.2013.09.002

M3 - Article (Academic Journal)

SN - 1874-3900

VL - 7

SP - 6

EP - 10

JO - Phytochemistry letters

JF - Phytochemistry letters

ER -

Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity

Abstract

Keywords

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3-month Core Capability for Chemistry Research

A 500MHZ NMR SPECTROMETER TO UNDERPIN CHEMICAL RESEARCH AT BRISTOL

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