Projects per year
MicroRNAs fine-tune gene expression by inhibiting the translation of mRNA targets. Argonaute (Ago) proteins are critical mediators of microRNA-induced post-transcriptional silencing and have been shown to associate with endosomal compartments, but the molecular mechanisms that underlie this process are unclear, especially in neurons. Here, we report a novel interaction between Ago2 and the BAR-domain protein, PICK1. We show that PICK1 promotes Ago2 localization at endosomal compartments in neuronal dendrites and inhibits Ago2 function in translational repression following neuronal stimulation. We propose that PICK1 provides a link between activity-dependent endosomal trafficking and local regulation of translation in neurons.
|Number of pages||9|
|Early online date||10 Apr 2014|
|Publication status||Published - 1 May 2014|
- synaptic plasticity
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- 1 Finished
Regulation of Arp2/3-mediated actin polymerisation by PICK1 in neuronal function.
10/01/11 → 10/06/14
Professor Jonathan G Hanley
- School of Biochemistry - Professor of Molecular Neuroscience
- Fundamental Bioscience
- Dynamic Cell Biology
- Bristol Neuroscience
Person: Academic , Member