PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.

Anna Antoniou, Marcio Baptista, Nick Carney, Jonathan Hanley

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)
422 Downloads (Pure)

Abstract

MicroRNAs fine-tune gene expression by inhibiting the translation of mRNA targets. Argonaute (Ago) proteins are critical mediators of microRNA-induced post-transcriptional silencing and have been shown to associate with endosomal compartments, but the molecular mechanisms that underlie this process are unclear, especially in neurons. Here, we report a novel interaction between Ago2 and the BAR-domain protein, PICK1. We show that PICK1 promotes Ago2 localization at endosomal compartments in neuronal dendrites and inhibits Ago2 function in translational repression following neuronal stimulation. We propose that PICK1 provides a link between activity-dependent endosomal trafficking and local regulation of translation in neurons.
Original languageEnglish
Pages (from-to)548-556
Number of pages9
JournalEMBO Reports
Volume15
Issue number5
Early online date10 Apr 2014
DOIs
Publication statusPublished - 1 May 2014

Keywords

  • RISC
  • synaptic plasticity
  • trafficking

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