Placental growth factor testing for suspected pre-eclampsia: a cost-effectiveness analysis

K. E. Duhig*, P. T. Seed, J E Myers, R. Bahl, G. Bambridge, S. Barnfield, J. Ficquet, J. C. Girling, A Khalil, A. H. Shennan, L. C. Chappell, R M Hunter

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)
160 Downloads (Pure)


Objective: To calculate the cost-effectiveness of implementing PlGF testing alongside a clinical management algorithm in maternity services in the UK, compared with current standard care. Design: Cost-effectiveness analysis. Setting: Eleven maternity units participating in the PARROT stepped-wedge cluster-randomised controlled trial. Population: Women presenting with suspected pre-eclampsia between 20+0 and 36+6 weeks’ gestation. Methods: Monte Carlo simulation utilising resource use data and maternal adverse outcomes. Main outcome measures: Cost per maternal adverse outcome prevented. Results: Clinical care with PlGF testing costs less than current standard practice and resulted in fewer maternal adverse outcomes. There is a total cost-saving of UK£149 per patient tested, when including the cost of the test. This represents a potential cost-saving of UK£2,891,196 each year across the NHS in England. Conclusions: Clinical care with PlGF testing is associated with the potential for cost-savings per participant tested when compared with current practice via a reduction in outpatient attendances, and improves maternal outcomes. This economic analysis supports a role for implementation of PlGF testing in antenatal services for the assessment of women with suspected pre-eclampsia. Tweetable abstract: Placental growth factor testing for suspected pre-eclampsia is cost-saving and improves maternal outcomes.

Original languageEnglish
Pages (from-to)1390-1398
Number of pages9
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number11
Early online date4 Sept 2019
Publication statusPublished - 1 Oct 2019


  • Economic analysis
  • placental growth factor
  • pre-eclampsia


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