Abstract
The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother later in life. In this review, we argue that a woman’s pre-conception cardiovascular health drives both the development of placental syndromes and long-term cardiovascular risk but acknowledge that placental syndromes can also contribute to future cardiovascular risk independent of pre-conception health. We describe how preclinical studies in models of preeclampsia inform our understanding of the links with later cardiovascular disease, and how current pre-pregnancy studies may explain relative contributions of both pre-conception factors and the occurrence of placental syndromes to long-term cardiovascular disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1211–1224 |
| Number of pages | 14 |
| Journal | Clinical Science |
| Volume | 137 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 22 Aug 2023 |
Bibliographical note
Funding Information:This work was funded in whole, or in part, by Wellcome [grant number 221774/Z/20/Z]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. C.D. is supported by the British Heart Foundation [grant number RE/18/6/34217]. C.L. is supported by the NIHR Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London. The views expressed are those of the authors and not necessarily those of the NHS, Imperial College London, the NIHR or the Department of Health.
Publisher Copyright:
© 2023 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).