Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: New data and meta-analyses

Gordon D O Lowe, Katie Harris, Wolfgang Koenig, Yoav Ben-Shlomo, Barbara Thorand, Annette Peters, Christa Meisinger, Armin Imhof, Hugh Tunstall-Pedoe, Sanne A E Peters, Mark Woodward

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
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AIMS: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities.

METHODS: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study.

RESULTS: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95% CI 1.02 to 1.13), 1.03 (95% CI 0.94 to 1.14) and 1.01 (95% CI 0.96 to 1.06).

CONCLUSIONS: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.

Original languageEnglish
Article numberjcp-2022-208223
Pages (from-to)1-8
Number of pages8
JournalJournal of Clinical Pathology
Early online date24 Feb 2023
Publication statusE-pub ahead of print - 24 Feb 2023

Bibliographical note

Funding Information:
The MONICA/KORA study was initiated and financed by the Helmholtz Zentrum München-German Research Centre for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. The MONICA Glasgow and SHHEC studies were funded by the Scottish Health Department Chief Scientist Office; British Heart Foundation; and the FP Fleming Trust. Measurements of immunoglobulins in MONICA/KORA Augsburg and MONICA Glasgow have been made possible through intramural funds from the University of Ulm.

Publisher Copyright:
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.


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