Platelet dysfunction associated with the novel Trp29Cys thromboxane A₂ receptor variant

A D Mumford, S Nisar, L Darnige, M L Jones, C Bachelot-Loza, S Gandrille, F Zinzindohoue, A-M Fischer, S J Mundell, P Gaussem, UK GAPP Study Group

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)

Abstract

Genetic variations that affect the structure of the thromboxane A2 receptor (TP receptor) provide insights into the function of this key platelet and vascular receptor, but are very rare in unselected populations.
Original languageEnglish
Pages (from-to)547-54
Number of pages8
JournalLitte<acute>ratures classiques (Title of volume: The<acute>a<circumflex>tre et musique au XVIIe sie<grave>cle) (Editor of issue: C. Mazouer)
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2013

Bibliographical note

© 2012 International Society on Thrombosis and Haemostasis.

Keywords

  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • Blood Coagulation Disorders
  • Blood Platelets
  • Calcium
  • Enzyme-Linked Immunosorbent Assay
  • Genetic Predisposition to Disease
  • Genetic Variation
  • HEK293 Cells
  • Humans
  • Hydrazines
  • Ligands
  • Male
  • Microscopy, Fluorescence
  • Middle Aged
  • Phenotype
  • Platelet Aggregation
  • Radioligand Assay
  • Receptors, Thromboxane A2, Prostaglandin H2
  • Transfection

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