Projects per year
Abstract
Biomimetic carbohydrate receptors (“synthetic lectins”) have potential as agents for biological research and medicine. However, although effective strategies are available for “all-equatorial” carbohydrates (glucose, etc.), the recognition of other types of saccharide under natural (aqueous) conditions is less well developed. Herein we report a new approach based on a pyrene platform with polar arches extending from aryl substituents. The receptors are compatible with axially substituted carbohydrates, and also feature two identical binding sites, thus mimicking the multivalency observed for natural lectins. A variant with negative charges forms 1:2 host/guest complexes with aminosugars, with K1>3000 m−1 for axially substituted mannosamine, whereas a positively charged version binds the important α-sialyl unit with K1≈1300 m−1.
Original language | English |
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Pages (from-to) | 9311–9315 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 55 |
Issue number | 32 |
Early online date | 17 Jun 2016 |
DOIs | |
Publication status | Published - 1 Aug 2016 |
Research Groups and Themes
- BCS and TECS CDTs
Keywords
- carbohydrates
- dendrimers
- molecular recognition
- receptors
- supramolecular chemistry
Fingerprint
Dive into the research topics of 'Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water'. Together they form a unique fingerprint.Projects
- 5 Finished
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A 13C NMR Coldprobe to Underpin Chemistry Research.
Butts, C. P. (Principal Investigator)
28/02/14 → 29/11/17
Project: Research
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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Reworking of Novel tools for Glycoscience
Galan, M. C. (Principal Investigator)
31/03/12 → 30/08/17
Project: Research
Profiles
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Professor Matthew P Crump
- School of Chemistry - Professor of NMR and Structural Biology
- Cancer
Person: Academic , Member
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Professor Anthony P Davis
- School of Chemistry - Professor of Supramolecular Chemistry
Person: Academic