Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)

NM Kane; Q Xiao; AH Baker; Z Luo; Q Xu; C Emanueli

doi:10.1016/j.pharmthera.2010.10.004

Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)

NM Kane, Q Xiao, AH Baker, Z Luo, Q Xu, C Emanueli

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

87 Citations (Scopus)

Abstract

Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.

Translated title of the contribution	Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)
Original language	English
Pages (from-to)	29 - 49
Number of pages	21
Journal	Pharmacol Ther
DOIs	https://doi.org/10.1016/j.pharmthera.2010.10.004
Publication status	Published - Jan 2011

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title = "Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)",

abstract = "Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.",

author = "NM Kane and Q Xiao and AH Baker and Z Luo and Q Xu and C Emanueli",

year = "2011",

month = jan,

doi = "10.1016/j.pharmthera.2010.10.004",

language = "English",

pages = "29 -- 49",

journal = "Pharmacol Ther",

publisher = "Wiley-Blackwell",

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T1 - Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)

AU - Kane, NM

AU - Xiao, Q

AU - Baker, AH

AU - Luo, Z

AU - Xu, Q

AU - Emanueli, C

PY - 2011/1

Y1 - 2011/1

N2 - Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.

AB - Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.

U2 - 10.1016/j.pharmthera.2010.10.004

DO - 10.1016/j.pharmthera.2010.10.004

M3 - Article (Academic Journal)

C2 - 20965210

SP - 29

EP - 49

JO - Pharmacol Ther

JF - Pharmacol Ther

ER -

Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)

Abstract

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