Polycystic ovary syndrome and pregnancy outcome: red herring or red flag?

D. Siassakos*, P. Wardle

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, associated with a characteristic ovarian appearance at ultrasound scan, hyperandrogenism, and ovulatory disorders. The pathogenesis appears to be mainly related to reduced insulin sensitivity in peripheral tissues, leading to hyperinsulinaemia. There is a wide variation in the severity of PCOS symptoms. Women with PCOS are believed to be predisposed to a variety of complications in pregnancy. We present a summary of the evidence surrounding these claims and discuss the weaknesses of the available to date studies.

Original languageEnglish
Pages (from-to)922-932
Number of pages11
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume114
Issue number8
DOIs
Publication statusPublished - Aug 2007

Keywords

  • GESTATIONAL DIABETES-MELLITUS
  • INSULIN-RESISTANCE
  • insulin
  • MIDDLE-AGED WOMEN
  • outcome
  • IMPAIRED GLUCOSE-TOLERANCE
  • ACTIVATOR INHIBITOR ACTIVITY
  • FACTOR-BINDING PROTEIN-1
  • PCOS
  • pregnancy
  • SERUM LUTEINIZING-HORMONE
  • IN-VITRO FERTILIZATION
  • C-REACTIVE PROTEIN
  • EPL
  • GRADE CHRONIC INFLAMMATION

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