Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Minh-Phuong Huynh-Le, Jenny L Donovan , Richard M Martin, Tyler M. Seibert, et al.

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, performance of a version compatible with OncoArray genotypes (PHS2) is evaluated in a multi-ethnic dataset of 80,491 men (49,916 prostate cancer cases, 30,575 controls). PHS2 was associated with age at diagnosis of any prostate cancer, aggressive prostate cancer (Gleason score ≥7, stage T3-T4, PSA≥10 ng/mL, or nodal/distant metastasis), and prostate cancer-specific death. In subgroup analyses, associations with prostate cancer were significant (p<10-16) within each genetic ancestry tested: European (n=71,856), Asian (n=2,382), and African (n=6,253). Comparing the 80th/20th genetic risk percentiles, hazard ratios for prostate cancer, aggressive prostate cancer, and prostate cancer-specific death were 5.3, 5.9, and 5.7, respectively. Within European, Asian, and African ancestries, analogous hazard ratios for prostate cancer were: 5.5, 4.5, and 2.5, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
Original languageEnglish
JournalNature Communications
Publication statusAccepted/In press - 12 Jan 2021

Structured keywords

  • ICEP

Keywords

  • Prostate cancer
  • Ethnicity
  • genetics
  • precision medicine
  • survival
  • hazard
  • risk factors

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