Abstract
A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, performance of a version compatible with OncoArray genotypes (PHS2) is evaluated in a multi-ethnic dataset of 80,491 men (49,916 prostate cancer cases, 30,575 controls). PHS2 was associated with age at diagnosis of any prostate cancer, aggressive prostate cancer (Gleason score ≥7, stage T3-T4, PSA≥10 ng/mL, or nodal/distant metastasis), and prostate cancer-specific death. In subgroup analyses, associations with prostate cancer were significant (p<10-16) within each genetic ancestry tested: European (n=71,856), Asian (n=2,382), and African (n=6,253). Comparing the 80th/20th genetic risk percentiles, hazard ratios for prostate cancer, aggressive prostate cancer, and prostate cancer-specific death were 5.3, 5.9, and 5.7, respectively. Within European, Asian, and African ancestries, analogous hazard ratios for prostate cancer were: 5.5, 4.5, and 2.5, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
| Original language | English |
|---|---|
| Article number | 1236 |
| Pages (from-to) | 1236 (2021) |
| Number of pages | 9 |
| Journal | Nature Communications |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Feb 2021 |
Research Groups and Themes
- ICEP
Keywords
- Prostate cancer
- Ethnicity
- genetics
- precision medicine
- survival
- hazard
- risk factors
Access to Document
- Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Springer Nature at https://doi.org/10.1038/s41467-021-21287-0. Please refer to any applicable terms of use of the publisher.
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Full-text PDF (author’s accepted manuscript)
Accepted author manuscript, 329 KB