A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, performance of a version compatible with OncoArray genotypes (PHS2) is evaluated in a multi-ethnic dataset of 80,491 men (49,916 prostate cancer cases, 30,575 controls). PHS2 was associated with age at diagnosis of any prostate cancer, aggressive prostate cancer (Gleason score ≥7, stage T3-T4, PSA≥10 ng/mL, or nodal/distant metastasis), and prostate cancer-specific death. In subgroup analyses, associations with prostate cancer were significant (p<10-16) within each genetic ancestry tested: European (n=71,856), Asian (n=2,382), and African (n=6,253). Comparing the 80th/20th genetic risk percentiles, hazard ratios for prostate cancer, aggressive prostate cancer, and prostate cancer-specific death were 5.3, 5.9, and 5.7, respectively. Within European, Asian, and African ancestries, analogous hazard ratios for prostate cancer were: 5.5, 4.5, and 2.5, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
|Publication status||Accepted/In press - 12 Jan 2021|
- Prostate cancer
- precision medicine
- risk factors