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Polygenic risk score for Alzheimer’s disease and trajectories of cardiometabolic risk factors in children

Research output: Contribution to journalArticle

Original languageEnglish
Article number125
Number of pages10
JournalWellcome Open Research
Volume4
DOIs
DateAccepted/In press - 7 Aug 2019
DatePublished (current) - 20 Aug 2019

Abstract

Introduction:
Cardiometabolic factors are implicated in the aetiology of Alzheimer’s disease and may lie on the pathways linking genetic variants to Alzheimer’s disease across the life course. We examined whether polygenic risk scores (PRS) were associated with cardiometabolic health indicators through childhood and adolescence.

Methods:
In 7,977 participants from the Avon Longitudinal Study of Parents and Children, we tested whether a PRS for Alzheimer’s disease was associated with trajectories of cardiometabolic risk factors. We examined trajectories for height at 1-18 years; lean and fat mass at 9-18 years; systolic and diastolic blood pressure at 7-18 years; glucose and C-reactive protein at 9-18 years; insulin at 10-18 years; and high and low-density lipoproteins and triglycerides birth at 18 years. We also examined birthweight and interleukin-6 (IL-6) at age 9 years and physical activity at ages 11, 12, and 15 years.

Results:
No consistent associations were observed between the PRS excluding genetic variants in the apolipoprotein E gene region and cardiometabolic factors trajectories across childhood and adolescence.

Conclusions:
We did not detect evidence to suggest that the PRS for Alzheimer’s disease acts through childhood and adolescent cardiometabolic risk factors. Further studies should examine whether these associations emerge later in adulthood when variation in cardiometabolic risk factors is likely to be greater.

    Research areas

  • cardiometabolic, trajectories, polygenic risk scores, Alzheimer's disease

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via The Wellcome Trust at https://wellcomeopenresearch.org/articles/4-125/v1. Please refer to any applicable terms of use of the publisher.

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