Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets

Russell J. Cox

Research output: Contribution to journalArticle (Academic Journal)

292 Citations (Scopus)


Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.

Original languageEnglish
Pages (from-to)2010-2026
Number of pages17
JournalOrganic and Biomolecular Chemistry
Issue number13
Publication statusPublished - 2007

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