Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Stanley Zammit; Gaynor Jones; Susan J. Jones; Nadine Norton; Robert D. Sanders; Charis Milham; Geraldine M. McCarthy; Lisa A. Jones; Alastair G. Cardno; Marion Gray; Kieran C. Murphy; Michael Conlon O'Donovan; Michael John Owen

doi:10.1002/ajmg.b.30021

Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia

Stanley Zammit, Gaynor Jones, Susan J. Jones, Nadine Norton, Robert D. Sanders, Charis Milham, Geraldine M. McCarthy, Lisa A. Jones, Alastair G. Cardno, Marion Gray, Kieran C. Murphy, Michael Conlon O'Donovan, Michael John Owen

Research output: Contribution to journal › Article (Academic Journal)

69 Citations (Scopus)

Abstract

Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.

Original language	English
Pages (from-to)	19-20
Number of pages	2
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	128B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.30021
Publication status	Published - 1 Jul 2004

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Zammit, S., Jones, G., Jones, S. J., Norton, N., Sanders, R. D., Milham, C., McCarthy, G. M., Jones, L. A., Cardno, A. G., Gray, M., Murphy, K. C., O'Donovan, M. C., & Owen, M. J. (2004). Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 128B(1), 19-20. https://doi.org/10.1002/ajmg.b.30021

Zammit, Stanley ; Jones, Gaynor ; Jones, Susan J. ; Norton, Nadine ; Sanders, Robert D. ; Milham, Charis ; McCarthy, Geraldine M. ; Jones, Lisa A. ; Cardno, Alastair G. ; Gray, Marion ; Murphy, Kieran C. ; O'Donovan, Michael Conlon ; Owen, Michael John. / Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2004 ; Vol. 128B, No. 1. pp. 19-20.

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title = "Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia",

abstract = "Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.",

author = "Stanley Zammit and Gaynor Jones and Jones, {Susan J.} and Nadine Norton and Sanders, {Robert D.} and Charis Milham and McCarthy, {Geraldine M.} and Jones, {Lisa A.} and Cardno, {Alastair G.} and Marion Gray and Murphy, {Kieran C.} and O'Donovan, {Michael Conlon} and Owen, {Michael John}",

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Zammit, S, Jones, G, Jones, SJ, Norton, N, Sanders, RD, Milham, C, McCarthy, GM, Jones, LA, Cardno, AG, Gray, M, Murphy, KC, O'Donovan, MC & Owen, MJ 2004, 'Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 128B, no. 1, pp. 19-20. https://doi.org/10.1002/ajmg.b.30021

Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. / Zammit, Stanley; Jones, Gaynor; Jones, Susan J.; Norton, Nadine; Sanders, Robert D.; Milham, Charis; McCarthy, Geraldine M.; Jones, Lisa A.; Cardno, Alastair G.; Gray, Marion; Murphy, Kieran C.; O'Donovan, Michael Conlon; Owen, Michael John.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 128B, No. 1, 01.07.2004, p. 19-20.

Research output: Contribution to journal › Article (Academic Journal)

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AB - Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.

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