Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish

Nadja R. Brun*, Patrick van Hage, Ellard R. Hunting, Anna Pavlina G. Haramis, Suzanne C. Vink, Martina G. Vijver, Marcel J.M. Schaaf, Christian Tudorache

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

30 Citations (Scopus)
104 Downloads (Pure)

Abstract

Plastic nanoparticles originating from weathering plastic waste are emerging contaminants in aquatic environments, with unknown modes of action in aquatic organisms. Recent studies suggest that internalised nanoplastics may disrupt processes related to energy metabolism. Such disruption can be crucial for organisms during development and may ultimately lead to changes in behaviour. Here, we investigated the link between polystyrene nanoplastic (PSNP)-induced signalling events and behavioural changes. Larval zebrafish exhibited PSNP accumulation in the pancreas, which coincided with a decreased glucose level. By using hyperglycemic and glucocorticoid receptor (Gr) mutant larvae, we demonstrate that the PSNP-induced disruption in glucose homoeostasis coincided with increased cortisol secretion and hyperactivity in challenge phases. Our work sheds new light on a potential mechanism underlying nanoplastics toxicity in fish, suggesting that the adverse effect of PSNPs are at least in part mediated by Gr activation in response to disrupted glucose homeostasis, ultimately leading to aberrant locomotor activity.

Original languageEnglish
Article number382
Number of pages9
JournalCommunications Biology
Volume2
DOIs
Publication statusPublished - 18 Oct 2019

Keywords

  • Behavioural ecology
  • Behavioural methods
  • Predictive markers
  • Toxicology
  • Zebrafish

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