Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study

BW Wheeler, C Metcalfe, DJ Gunnell, P Stephens, RM Martin

Research output: Contribution to journalArticle (Academic Journal)peer-review

13 Citations (Scopus)

Abstract

Aim To investigate impacts of withdrawal and regulatory advice regarding cyclo-oxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction. Methods Ecological time-series study of prescribing, mortality and hospital admission trends in people aged ≥ 55 years. Results Withdrawal and regulatory advice limiting COX-2 inhibitor availability from 2004 was temporally associated with reversal of previously unfavourable trends in emergency myocardial infarction (MI) admissions amongst people aged ≥ 65. Annual admission rate trends changed from +4.6% to -3.1% (p
Translated title of the contributionPopulation impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study
Original languageEnglish
Pages (from-to)752 - 764
Number of pages13
JournalBritish Journal of Clinical Pharmacology
Volume68 (5)
DOIs
Publication statusPublished - Jul 2009

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