Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study

BW Wheeler; C Metcalfe; DJ Gunnell; P Stephens; RM Martin

doi:10.1111/j.1365-2125.2009.03500.x

Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study

BW Wheeler, C Metcalfe, DJ Gunnell, P Stephens, RM Martin

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Abstract

Aim To investigate impacts of withdrawal and regulatory advice regarding cyclo-oxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction. Methods Ecological time-series study of prescribing, mortality and hospital admission trends in people aged ≥ 55 years. Results Withdrawal and regulatory advice limiting COX-2 inhibitor availability from 2004 was temporally associated with reversal of previously unfavourable trends in emergency myocardial infarction (MI) admissions amongst people aged ≥ 65. Annual admission rate trends changed from +4.6% to -3.1% (p

Translated title of the contribution	Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study
Original language	English
Pages (from-to)	752 - 764
Number of pages	13
Journal	British Journal of Clinical Pharmacology
Volume	68 (5)
DOIs	https://doi.org/10.1111/j.1365-2125.2009.03500.x
Publication status	Published - Jul 2009

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title = "Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study",

abstract = "Aim To investigate impacts of withdrawal and regulatory advice regarding cyclo-oxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction. Methods Ecological time-series study of prescribing, mortality and hospital admission trends in people aged ≥ 55 years. Results Withdrawal and regulatory advice limiting COX-2 inhibitor availability from 2004 was temporally associated with reversal of previously unfavourable trends in emergency myocardial infarction (MI) admissions amongst people aged ≥ 65. Annual admission rate trends changed from +4.6% to -3.1% (p",

author = "BW Wheeler and C Metcalfe and DJ Gunnell and P Stephens and RM Martin",

year = "2009",

month = jul,

doi = "10.1111/j.1365-2125.2009.03500.x",

language = "English",

volume = "68 (5)",

pages = "752 -- 764",

journal = "British Journal of Clinical Pharmacology",

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T1 - Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study

AU - Wheeler, BW

AU - Metcalfe, C

AU - Gunnell, DJ

AU - Stephens, P

AU - Martin, RM

PY - 2009/7

Y1 - 2009/7

N2 - Aim To investigate impacts of withdrawal and regulatory advice regarding cyclo-oxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction. Methods Ecological time-series study of prescribing, mortality and hospital admission trends in people aged ≥ 55 years. Results Withdrawal and regulatory advice limiting COX-2 inhibitor availability from 2004 was temporally associated with reversal of previously unfavourable trends in emergency myocardial infarction (MI) admissions amongst people aged ≥ 65. Annual admission rate trends changed from +4.6% to -3.1% (p

AB - Aim To investigate impacts of withdrawal and regulatory advice regarding cyclo-oxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction. Methods Ecological time-series study of prescribing, mortality and hospital admission trends in people aged ≥ 55 years. Results Withdrawal and regulatory advice limiting COX-2 inhibitor availability from 2004 was temporally associated with reversal of previously unfavourable trends in emergency myocardial infarction (MI) admissions amongst people aged ≥ 65. Annual admission rate trends changed from +4.6% to -3.1% (p

U2 - 10.1111/j.1365-2125.2009.03500.x

DO - 10.1111/j.1365-2125.2009.03500.x

M3 - Article (Academic Journal)

C2 - 19917000

SN - 1365-2125

VL - 68 (5)

SP - 752

EP - 764

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

ER -

Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study

Abstract

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