Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort

Tamsin H Sharp; Nancy S McBride; Amy E Howell; C John Evans; Derek K Jones; Gavin Perry; Stavros I Dimitriadis; Thomas M Lancaster; Luisa Zuccolo; Caroline Relton; Sarah M Matthews; Thomas Breeze; Anthony S David; Mark Drakesmith; David E J Linden; Tomas Paus; Esther Walton

doi:10.12688/wellcomeopenres.16060.1

Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort

Tamsin H Sharp^*, Nancy S McBride, Amy E Howell, C John Evans, Derek K Jones, Gavin Perry, Stavros I Dimitriadis, Thomas M Lancaster, Luisa Zuccolo, Caroline Relton, Sarah M Matthews, Thomas Breeze, Anthony S David, Mark Drakesmith, David E J Linden, Tomas Paus, Esther Walton

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Study of Parents and Children, a prospective multigenerational pregnancy and birth cohort based in the United Kingdom. Brain imaging data were acquired when offspring were between 18 and 24 years of age, and included acquisition of structural, functional and magnetization transfer magnetic resonance, diffusion tensor, and magnetoencephalography imaging. This resource provides a unique opportunity to combine neuroimaging data with extensive phenotypic and genotypic measures from participants, their mothers, and fathers.

Original language	English
Number of pages	17
Journal	Wellcome Open Research
Early online date	28 Aug 2020
DOIs	https://doi.org/10.12688/wellcomeopenres.16060.1
Publication status	Published - 28 Aug 2020

Keywords

neurodevelopment
neuroimaging
brain morphology
brain function
ALSPAC
population health
birth cohort
MRI

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10.12688/wellcomeopenres.16060.1

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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
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Project: Research
IEU 2 Relton Programme - Epigenetic Epidemiology
Relton, C. L. (Principal Investigator)
1/04/18 → 31/03/23
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Sharp, T. H., McBride, N. S., Howell, A. E., Evans, C. J., Jones, D. K., Perry, G., Dimitriadis, S. I., Lancaster, T. M., Zuccolo, L., Relton, C., Matthews, S. M., Breeze, T., David, A. S., Drakesmith, M., Linden, D. E. J., Paus, T., & Walton, E. (2020). Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort. Wellcome Open Research. https://doi.org/10.12688/wellcomeopenres.16060.1

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title = "Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort",

abstract = "Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Study of Parents and Children, a prospective multigenerational pregnancy and birth cohort based in the United Kingdom. Brain imaging data were acquired when offspring were between 18 and 24 years of age, and included acquisition of structural, functional and magnetization transfer magnetic resonance, diffusion tensor, and magnetoencephalography imaging. This resource provides a unique opportunity to combine neuroimaging data with extensive phenotypic and genotypic measures from participants, their mothers, and fathers.",

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author = "Sharp, {Tamsin H} and McBride, {Nancy S} and Howell, {Amy E} and Evans, {C John} and Jones, {Derek K} and Gavin Perry and Dimitriadis, {Stavros I} and Lancaster, {Thomas M} and Luisa Zuccolo and Caroline Relton and Matthews, {Sarah M} and Thomas Breeze and David, {Anthony S} and Mark Drakesmith and Linden, {David E J} and Tomas Paus and Esther Walton",

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Sharp, TH, McBride, NS , Howell, AE, Evans, CJ, Jones, DK, Perry, G, Dimitriadis, SI, Lancaster, TM, Zuccolo, L, Relton, C, Matthews, SM, Breeze, T, David, AS, Drakesmith, M, Linden, DEJ, Paus, T & Walton, E 2020, 'Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort', Wellcome Open Research. https://doi.org/10.12688/wellcomeopenres.16060.1

TY - JOUR

T1 - Population neuroimaging

T2 - generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort

AU - Sharp, Tamsin H

AU - McBride, Nancy S

AU - Howell, Amy E

AU - Evans, C John

AU - Jones, Derek K

AU - Perry, Gavin

AU - Dimitriadis, Stavros I

AU - Lancaster, Thomas M

AU - Zuccolo, Luisa

AU - Relton, Caroline

AU - Matthews, Sarah M

AU - Breeze, Thomas

AU - David, Anthony S

AU - Drakesmith, Mark

AU - Linden, David E J

AU - Paus, Tomas

AU - Walton, Esther

PY - 2020/8/28

Y1 - 2020/8/28

N2 - Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Study of Parents and Children, a prospective multigenerational pregnancy and birth cohort based in the United Kingdom. Brain imaging data were acquired when offspring were between 18 and 24 years of age, and included acquisition of structural, functional and magnetization transfer magnetic resonance, diffusion tensor, and magnetoencephalography imaging. This resource provides a unique opportunity to combine neuroimaging data with extensive phenotypic and genotypic measures from participants, their mothers, and fathers.

AB - Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Study of Parents and Children, a prospective multigenerational pregnancy and birth cohort based in the United Kingdom. Brain imaging data were acquired when offspring were between 18 and 24 years of age, and included acquisition of structural, functional and magnetization transfer magnetic resonance, diffusion tensor, and magnetoencephalography imaging. This resource provides a unique opportunity to combine neuroimaging data with extensive phenotypic and genotypic measures from participants, their mothers, and fathers.

KW - neurodevelopment

KW - neuroimaging

KW - brain morphology

KW - brain function

KW - ALSPAC

KW - population health

KW - birth cohort

KW - MRI

U2 - 10.12688/wellcomeopenres.16060.1

DO - 10.12688/wellcomeopenres.16060.1

M3 - Article (Academic Journal)

C2 - 33043145

SN - 2398-502X

JO - Wellcome Open Research

JF - Wellcome Open Research

ER -

Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort

Abstract

Keywords

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Projects

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

IEU 2 Relton Programme - Epigenetic Epidemiology

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