Population phenomena inflate genetic associations of complex social traits

Tim T Morris*, Neil M Davies, Gibran Hemani, George Davey Smith

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

Heritability, genetic correlation and genetic associations estimated from samples of unrelated individuals are often perceived as confirmation that genotype causes the phenotype(s). However, these estimates can arise from indirect mechanisms due to population phenomena including population stratification, dynastic effects, and assortative mating. We introduce these, describe how they can bias or inflate genotype-phenotype associations, and demonstrate methods that can be used to assess their presence. Using data on educational achievement and parental socioeconomic position as an exemplar, we demonstrate that both heritability and genetic correlation may be biased estimates of the causal contribution of genotype. These results highlight the limitations of genotype-phenotype estimates obtained from samples of unrelated individuals. Use of these methods in combination with family-based designs may offer researchers greater opportunities to explore the mechanisms driving genotype-phenotype associations and identify the causes of estimate bias.
Original languageEnglish
Article numbereaay0328
Number of pages13
JournalScience Advances
Volume6
Issue number16
DOIs
Publication statusPublished - 15 Apr 2020

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Keywords

  • Genetics
  • education
  • socioeconomic
  • heritability
  • confounding
  • bias
  • ALSPAC

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