Skip to content

Population phenomena inflate genetic associations of complex social traits

Research output: Contribution to journalArticle

Original languageEnglish
JournalScience Advances
DateAccepted/In press - 17 Jan 2020

Abstract

Heritability, genetic correlation and genetic associations estimated from samples of unrelated individuals are often perceived as confirmation that genotype causes the phenotype(s). However, these estimates can arise from indirect mechanisms due to population phenomena including population stratification, dynastic effects, and assortative mating. We introduce these, describe how they can bias or inflate genotype-phenotype associations, and demonstrate methods that can be used to assess their presence. Using data on educational achievement and parental socioeconomic position as an exemplar, we demonstrate that both heritability and genetic correlation may be biased estimates of the causal contribution of genotype. These results highlight the limitations of genotype-phenotype estimates obtained from samples of unrelated individuals. Use of these methods in combination with family-based designs may offer researchers greater opportunities to explore the mechanisms driving genotype-phenotype associations and identify the causes of estimate bias.

    Research areas

  • Genetics, education, socioeconomic, heritability, confounding, bias, ALSPAC

Documents

Documents

  • Full-text PDF (accepted author manuscript)

    Accepted author manuscript, 632 KB, PDF document

    Embargo ends: 1/01/99

    Request copy

View research connections

Related faculties, schools or groups