Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders

S. Ghorashian; R. Sanderson; J. Lee; A. Black; M. A. O'Reilly; D. I. Marks; J. Snowden; D. Richardson; E. Olavarria

doi:10.1111/bjh.70247

Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders

S. Ghorashian^*, R. Sanderson, J. Lee, A. Black, M. A. O'Reilly, D. I. Marks, J. Snowden, D. Richardson, E. Olavarria

^*Corresponding author for this work

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Abstract

[no abstract]

Original language	English
Journal	British Journal of Haematology
Early online date	25 Nov 2025
DOIs	https://doi.org/10.1111/bjh.70247
Publication status	E-pub ahead of print - 25 Nov 2025

Keywords

gene therapy
CAR T cell therapy
cell therapy

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Ghorashian, S., Sanderson, R., Lee, J., Black, A., O'Reilly, M. A., Marks, D. I., Snowden, J., Richardson, D., & Olavarria, E. (2025). Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders. British Journal of Haematology. Advance online publication. https://doi.org/10.1111/bjh.70247

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title = "Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders",

abstract = "[no abstract]",

keywords = "gene therapy, CAR T cell therapy, cell therapy",

author = "S. Ghorashian and R. Sanderson and J. Lee and A. Black and O'Reilly, \{M. A.\} and Marks, \{D. I.\} and J. Snowden and D. Richardson and E. Olavarria",

year = "2025",

month = nov,

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journal = "British Journal of Haematology",

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Ghorashian, S, Sanderson, R, Lee, J, Black, A, O'Reilly, MA, Marks, DI, Snowden, J, Richardson, D & Olavarria, E 2025, 'Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders', British Journal of Haematology. https://doi.org/10.1111/bjh.70247

Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders. / Ghorashian, S.; Sanderson, R.; Lee, J. et al.
In: British Journal of Haematology, 25.11.2025.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

TY - JOUR

T1 - Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders

AU - Ghorashian, S.

AU - Sanderson, R.

AU - Lee, J.

AU - Black, A.

AU - O'Reilly, M. A.

AU - Marks, D. I.

AU - Snowden, J.

AU - Richardson, D.

AU - Olavarria, E.

PY - 2025/11/25

Y1 - 2025/11/25

N2 - [no abstract]

AB - [no abstract]

KW - gene therapy

KW - CAR T cell therapy

KW - cell therapy

U2 - 10.1111/bjh.70247

DO - 10.1111/bjh.70247

M3 - Letter (Academic Journal)

C2 - 41287902

SN - 0007-1048

JO - British Journal of Haematology

JF - British Journal of Haematology

ER -

Ghorashian S, Sanderson R, Lee J, Black A, O'Reilly MA, Marks DI et al. Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders. British Journal of Haematology. 2025 Nov 25. Epub 2025 Nov 25. doi: 10.1111/bjh.70247