Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.

Michaela Gregorova, Daniel Morse, Tarcisio Brignoli, Joseph Steventon, Fergus W Hamilton, Laura Rivino*, Ruth C Massey*

*Corresponding author for this work

Research output: Working paperWorking paper and Preprints

Abstract

Here we describe the case of a COVID-19 patient who developed recurring ventilator23 associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels 24 of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed 25 the AMR genotype, while immunological analysis revealed massive and escalating levels of 26 T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander 27 activated, which may have contributed to this patient’s persistent symptoms and radiological 28 changes.
Original languageEnglish
DOIs
Publication statusSubmitted - 2020

Structured keywords

  • Covid19

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