TY - UNPB
T1 - Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
AU - Gregorova, Michaela
AU - Morse, Daniel
AU - Brignoli, Tarcisio
AU - Steventon, Joseph
AU - Hamilton, Fergus W
AU - Rivino, Laura
AU - Massey, Ruth C
PY - 2020
Y1 - 2020
N2 - Here we describe the case of a COVID-19 patient who developed recurring ventilator23 associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels 24 of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed 25 the AMR genotype, while immunological analysis revealed massive and escalating levels of 26 T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander 27 activated, which may have contributed to this patient’s persistent symptoms and radiological 28 changes.
AB - Here we describe the case of a COVID-19 patient who developed recurring ventilator23 associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels 24 of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed 25 the AMR genotype, while immunological analysis revealed massive and escalating levels of 26 T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander 27 activated, which may have contributed to this patient’s persistent symptoms and radiological 28 changes.
U2 - 10.1101/2020.09.17.20190033
DO - 10.1101/2020.09.17.20190033
M3 - Working paper
BT - Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
ER -