Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring AMR bacterial pneumonia

Michaela Gregorova, Daniel Morse, Tarcisio Brignoli, Joseph Steventon, Fergus Hamilton, Mahableshwar Albur, David Arnold, Matthew Thomas, Alice Halliday, Holly Baum, Christopher Rice, Matthew B Avison, Andrew D Davidson, Marianna Santopaolo, Elizabeth Oliver, Anu Goenka, Adam Finn, Linda Wooldridge, Borko Amulic, Rosemary J BoytonDaniel M Altmann, David K Butler, Claire McMurray, Joanna Stockton, Sam Nicholls, Charles Cooper, Nicholas Loman, Michael J Cox, Laura Rivino, Ruth C Massey

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Here we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient's persistent symptoms and radiological changes.

Original languageEnglish
JournaleLife
Volume9
Early online date17 Dec 2020
DOIs
Publication statusE-pub ahead of print - 17 Dec 2020

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