TY - JOUR
T1 - Post-translational modifications of Parkinson's disease-related proteins
T2 - Phosphorylation, SUMOylation and Ubiquitination
AU - Junqueira, Stella C
AU - Centeno, Eduarda G Z
AU - Wilkinson, Kevin
AU - Cimarosti, Helena I
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the nigrostriatal pathway. The etiology of PD remains unclear and most cases are sporadic, however genetic mutations in more than 20 proteins have been shown to cause inherited forms of PD. Many of these proteins are linked to mitochondrial function, defects in which are a central characteristic of PD. Post-translational modifications (PTMs) allow rapid and reversible control over protein function. Largely focussing on mitochondrial dysfunction in PD, here we review findings on the PTMs phosphorylation, SUMOylation and ubiquitination that have been shown to affect PD-related proteins.
AB - Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the nigrostriatal pathway. The etiology of PD remains unclear and most cases are sporadic, however genetic mutations in more than 20 proteins have been shown to cause inherited forms of PD. Many of these proteins are linked to mitochondrial function, defects in which are a central characteristic of PD. Post-translational modifications (PTMs) allow rapid and reversible control over protein function. Largely focussing on mitochondrial dysfunction in PD, here we review findings on the PTMs phosphorylation, SUMOylation and ubiquitination that have been shown to affect PD-related proteins.
KW - Parkinson's disease
KW - Phosphorylation
KW - Post-translational modifications
KW - SUMOylation
KW - Ubiquitination
UR - http://www.scopus.com/inward/record.url?scp=85056590211&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2018.10.025
DO - 10.1016/j.bbadis.2018.10.025
M3 - Article (Academic Journal)
C2 - 30412791
AN - SCOPUS:85056590211
SN - 0925-4439
VL - 1865
SP - 2001
EP - 2007
JO - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
IS - 8
ER -