Pre-conception inter-pregnancy interval and risk of schizophrenia

Lihini Gunawardana; George Davey Smith; Stanley Zammit; Elise Whitley; David Gunnell; Sarah Lewis; Finn Rasmussen

doi:10.1192/bjp.bp.111.092916

Pre-conception inter-pregnancy interval and risk of schizophrenia

Lihini Gunawardana, George Davey Smith, Stanley Zammit, Elise Whitley, David Gunnell, Sarah Lewis, Finn Rasmussen

Research output: Contribution to journal › Article (Academic Journal)

31 Citations (Scopus)

Abstract

It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.

Original language	English
Pages (from-to)	338-339
Number of pages	2
Journal	British Journal of Psychiatry
Volume	199
Issue number	4
DOIs	https://doi.org/10.1192/bjp.bp.111.092916
Publication status	Published - 1 Oct 2011

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CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G.
1/09/07 → 1/09/13
Project: Research

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abstract = "It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.",

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AU - Gunawardana, Lihini

AU - Smith, George Davey

AU - Zammit, Stanley

AU - Whitley, Elise

AU - Gunnell, David

AU - Lewis, Sarah

AU - Rasmussen, Finn

PY - 2011/10/1

Y1 - 2011/10/1

N2 - It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.

AB - It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.

UR - http://orca.cf.ac.uk/29187/

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M3 - Article (Academic Journal)

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EP - 339

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 4

ER -

Pre-conception inter-pregnancy interval and risk of schizophrenia

Abstract

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