Pre-emptive hypoxia-regulated HO-1 gene therapy improves post-ischaemic limb perfusion and tissue regeneration in mice

Agnieszka Jazwa, Jacek Stepniewski, Martin Zamykal, Jolanta Jagodzinska, Marco Meloni, Costanza Emanueli, Alicja Jozkowicz, Jozef Dulak

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Abstract

Haem oxygenase-1 (HO-1) is a haem-degrading enzyme that generates carbon monoxide, bilirubin, and iron ions. Through these compounds, HO-1 mitigates cellular injury by exerting antioxidant, anti-apoptotic, and anti-inflammatory effects. Here, we examined the influence of HO-1 deficiency and transient hypoxia/ischaemia-induced HO-1 overexpression on post-injury hindlimb recovery.
Original languageEnglish
Pages (from-to)115-24
Number of pages10
JournalCardiovascular Research
Volume97
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Animals
  • Apoptosis
  • Cell Hypoxia
  • Cells, Cultured
  • Chemokine CXCL1
  • Disease Models, Animal
  • Endothelial Cells
  • Genetic Therapy
  • Heme Oxygenase-1
  • Hindlimb
  • Humans
  • Hydrogen Peroxide
  • Inflammation Mediators
  • Interleukin-6
  • Ischemia
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • MicroRNAs
  • Muscle Development
  • Muscle, Skeletal
  • MyoD Protein
  • Myogenin
  • Necrosis
  • Neovascularization, Physiologic
  • Oxidants
  • PAX7 Transcription Factor
  • Recovery of Function
  • Regeneration
  • Regional Blood Flow
  • Response Elements
  • Time Factors

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