Predicting motor, cognitive and functional impairment in Parkinson’s

Christine Lo, Siddharth Arora, Fahd Baig, Michael Lawton, Claire El Moulden, Thomas R Barber, Claudio Ruffmann, Johannes Klein, Peter Brown, Yoav Ben-Shlomo, Maarten de Vos, Michele T Hu

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)
110 Downloads (Pure)


We recently demonstrated that 998 features derived from a simple 7-minute smartphone test could distinguish between controls, people with Parkinson’s and people with idiopathic Rapid Eye Movement sleep behaviour disorder, with mean sensitivity/specificity values of 84.6-91.9%. Here we investigate whether the same smartphone features can be used to predict future clinically relevant outcomes in early Parkinson’s.

237 participants with Parkinson’s (mean (SD) disease duration 3.5 (2.2) years) in the Oxford Discovery cohort performed smartphone tests in clinic and at home. Each test assessed voice, balance, gait, reaction time, dexterity, rest and postural tremor. In addition, standard motor, cognitive and functional assessments and questionnaires were administered in clinic. Machine learning algorithms were trained to predict the onset of clinical outcomes provided at the next 18-month follow up visit using baseline smartphone recordings alone. The accuracy of model predictions was assessed using 10-fold and subject-wise cross validation schemes.

Baseline smartphone tests predicted the new onset of falls, freezing, postural instability, cognitive impairment and functional impairment at 18 months. For all outcome predictions AUC values were greater than 0.90 for 10-fold cross validation using all smartphone features. Using only the 30 most salient features, AUC values greater than 0.75 were obtained.

We demonstrate the ability to predict key future clinical outcomes using a simple smartphone test. This work has the potential to introduce individualised predictions to routine care, helping to target interventions to those most likely to benefit, with the aim of improving their outcome.
Original languageEnglish
Pages (from-to)1498-1509
Number of pages12
JournalAnnals of Clinical and Translational Neurology
Issue number8
Early online date26 Jul 2019
Publication statusPublished - 11 Aug 2019

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