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Predicting motor, cognitive and functional impairment in Parkinson’s

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1498-1509
Number of pages12
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number8
Early online date26 Jul 2019
DOIs
DateAccepted/In press - 3 Jul 2019
DateE-pub ahead of print - 26 Jul 2019
DatePublished (current) - 11 Aug 2019

Abstract

Objective:
We recently demonstrated that 998 features derived from a simple 7-minute smartphone test could distinguish between controls, people with Parkinson’s and people with idiopathic Rapid Eye Movement sleep behaviour disorder, with mean sensitivity/specificity values of 84.6-91.9%. Here we investigate whether the same smartphone features can be used to predict future clinically relevant outcomes in early Parkinson’s.

Methods:
237 participants with Parkinson’s (mean (SD) disease duration 3.5 (2.2) years) in the Oxford Discovery cohort performed smartphone tests in clinic and at home. Each test assessed voice, balance, gait, reaction time, dexterity, rest and postural tremor. In addition, standard motor, cognitive and functional assessments and questionnaires were administered in clinic. Machine learning algorithms were trained to predict the onset of clinical outcomes provided at the next 18-month follow up visit using baseline smartphone recordings alone. The accuracy of model predictions was assessed using 10-fold and subject-wise cross validation schemes.

Results:
Baseline smartphone tests predicted the new onset of falls, freezing, postural instability, cognitive impairment and functional impairment at 18 months. For all outcome predictions AUC values were greater than 0.90 for 10-fold cross validation using all smartphone features. Using only the 30 most salient features, AUC values greater than 0.75 were obtained.

Interpretation:
We demonstrate the ability to predict key future clinical outcomes using a simple smartphone test. This work has the potential to introduce individualised predictions to routine care, helping to target interventions to those most likely to benefit, with the aim of improving their outcome.

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Wiley at https://doi.org/10.1002/acn3.50853 . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

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