Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study

Natasha Martin; I F Robey; E A Gaffney; R J Gillies; R A Gatenby; P K Maini

doi:10.1038/bjc.2012.58

Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study

Natasha Martin, I F Robey, E A Gaffney, R J Gillies, R A Gatenby, P K Maini

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.

Original language	English
Pages (from-to)	1280-7
Number of pages	8
Journal	British Journal of Cancer
Volume	106
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2012.58
Publication status	Published - 27 Mar 2012

Keywords

Animals
Neoplasms
Bicarbonates
Hydrogen-Ion Concentration
Humans
Buffers
Mice
Models, Biological
Alkalosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study",

abstract = "Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.",

keywords = "Animals, Neoplasms, Bicarbonates, Hydrogen-Ion Concentration, Humans, Buffers, Mice, Models, Biological, Alkalosis",

author = "Natasha Martin and Robey, {I F} and Gaffney, {E A} and Gillies, {R J} and Gatenby, {R A} and Maini, {P K}",

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T2 - an integrative modelling study

AU - Martin, Natasha

AU - Robey, I F

AU - Gaffney, E A

AU - Gillies, R J

AU - Gatenby, R A

AU - Maini, P K

PY - 2012/3/27

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N2 - Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.

AB - Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.

KW - Animals

KW - Neoplasms

KW - Bicarbonates

KW - Hydrogen-Ion Concentration

KW - Humans

KW - Buffers

KW - Mice

KW - Models, Biological

KW - Alkalosis

U2 - 10.1038/bjc.2012.58

DO - 10.1038/bjc.2012.58

M3 - Article (Academic Journal)

C2 - 22382688

SN - 1532-1827

VL - 106

SP - 1280

EP - 1287

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 7

ER -

Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study

Abstract

Keywords

UN SDGs

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