Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study

Natasha Martin, I F Robey, E A Gaffney, R J Gillies, R A Gatenby, P K Maini

Research output: Contribution to journalArticle (Academic Journal)peer-review

28 Citations (Scopus)

Abstract

Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.
Original languageEnglish
Pages (from-to)1280-7
Number of pages8
JournalBritish Journal of Cancer
Volume106
Issue number7
DOIs
Publication statusPublished - 27 Mar 2012

Keywords

  • Animals
  • Neoplasms
  • Bicarbonates
  • Hydrogen-Ion Concentration
  • Humans
  • Buffers
  • Mice
  • Models, Biological
  • Alkalosis

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