Prediction of Ewing Sarcoma treatment outcome using attenuated tissue reflection FTIR tissue spectroscopy

Radosław Chaber*, Kornelia Łach, Christopher J. Arthur, Anna Raciborska, Elżbieta Michalak, Krzysztof Ciebiera, Katarzyna Bilska, Katarzyna Drabko, Józef Cebulski

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)
243 Downloads (Pure)

Abstract

Ewing sarcoma is the second most common type of primary bone cancer and predominantly affects children and young people. Improved outcome prediction is key to delivering risk-adjusted, appropriate and effective care to cancer patients. Advances in the Fourier Transform Infrared (FTIR) spectroscopy of tissues enable it to be a non-invasive method to obtain information about the biochemical content of any biological sample. In this retrospective study, attenuated tissue reflection FTIR spectroscopy of biopsy samples from paediatric patients reveals spectral features that are diagnostic for Ewing Sarcoma. Furthermore, our results suggest that spectral features such as these may be of value for the prediction of treatment outcome independent to well-known, routinely used risk factors.

Original languageEnglish
Article number12299
Number of pages8
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 17 Aug 2018

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