Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study

D. Prieto-Alhambra; A. Pagès-Castellà; G. Wallace; M.K. Javaid; A. Judge; X. Nogués; N.K. Arden; C. Cooper; A. Diez-Perez

doi:10.1002/jbmr.2011

Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study

D. Prieto-Alhambra, A. Pagès-Castellà, G. Wallace, M.K. Javaid, A. Judge, X. Nogués, N.K. Arden, C. Cooper, A. Diez-Perez

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

48 Citations (Scopus)

Abstract

Although oral bisphosphonates (BPs) are highly effective in preventing fractures, some patients will fracture while on treatment. We identified predictors of such fractures in a population-based cohort of incident users of oral BPs. We screened the Sistema d'Informació per al Desenvolupament de l'Investigació en Atenció Primària (SIDIAP) database to identify new users of oral BPs in 2006-2007. SIDIAP includes pharmacy invoice data and primary care electronic medical records for a representative 5 million people in Catalonia (Spain). Exclusion criteria were the following: Paget disease; 6 months of therapy. Incidence of fracture while on treatment was 3.4/100 person-years (95% confidence interval [CI], 3.1-3.7). Predictors of these among patients persisting and adhering to treatment included: older age (subhazard ratio [SHR] for 60 to

Original language	English
Pages (from-to)	268-274
Number of pages	7
Journal	Journal of Bone and Mineral Research
Volume	29
Issue number	1
DOIs	https://doi.org/10.1002/jbmr.2011
Publication status	Published - Jan 2014

Keywords

BISPHOSPHONATES
BONE
EPIDEMIOLOGY
FRACTURES
Administration, Oral
Adult
Aged
Aged, 80 and over
Body Mass Index
Cohort Studies
Databases, Factual
Diphosphonates
Female
Fractures, Bone
Hip Fractures
Humans
Incidence
Male
Middle Aged
Patient Compliance
Proton Pump Inhibitors
Risk Factors
Spain
Thinness
Vitamin D Deficiency

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title = "Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study",

abstract = "Although oral bisphosphonates (BPs) are highly effective in preventing fractures, some patients will fracture while on treatment. We identified predictors of such fractures in a population-based cohort of incident users of oral BPs. We screened the Sistema d'Informaci{\'o} per al Desenvolupament de l'Investigaci{\'o} en Atenci{\'o} Prim{\`a}ria (SIDIAP) database to identify new users of oral BPs in 2006-2007. SIDIAP includes pharmacy invoice data and primary care electronic medical records for a representative 5 million people in Catalonia (Spain). Exclusion criteria were the following: Paget disease; 6 months of therapy. Incidence of fracture while on treatment was 3.4/100 person-years (95% confidence interval [CI], 3.1-3.7). Predictors of these among patients persisting and adhering to treatment included: older age (subhazard ratio [SHR] for 60 to ",

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author = "D. Prieto-Alhambra and A. Pag{\`e}s-Castell{\`a} and G. Wallace and M.K. Javaid and A. Judge and X. Nogu{\'e}s and N.K. Arden and C. Cooper and A. Diez-Perez",

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language = "English",

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AU - Prieto-Alhambra, D.

AU - Pagès-Castellà, A.

AU - Wallace, G.

AU - Javaid, M.K.

AU - Judge, A.

AU - Nogués, X.

AU - Arden, N.K.

AU - Cooper, C.

AU - Diez-Perez, A.

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N2 - Although oral bisphosphonates (BPs) are highly effective in preventing fractures, some patients will fracture while on treatment. We identified predictors of such fractures in a population-based cohort of incident users of oral BPs. We screened the Sistema d'Informació per al Desenvolupament de l'Investigació en Atenció Primària (SIDIAP) database to identify new users of oral BPs in 2006-2007. SIDIAP includes pharmacy invoice data and primary care electronic medical records for a representative 5 million people in Catalonia (Spain). Exclusion criteria were the following: Paget disease; 6 months of therapy. Incidence of fracture while on treatment was 3.4/100 person-years (95% confidence interval [CI], 3.1-3.7). Predictors of these among patients persisting and adhering to treatment included: older age (subhazard ratio [SHR] for 60 to

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KW - Body Mass Index

KW - Cohort Studies

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KW - Proton Pump Inhibitors

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KW - Thinness

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ER -

Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study

Abstract

Keywords

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